Self‐Triggered Apoptosis Enzyme Prodrug Therapy (STAEPT): Enhancing Targeted Therapies via Recurrent Bystander Killing Effect by Exploiting Caspase‐Cleavable Linker

Tumor heterogeneity is associated with the therapeutic failures of targeted therapies. To overcome such heterogeneity, a novel targeted therapy is proposed that could kill tumor populations with diverse phenotypes by delivering nonselective cytotoxins to target‐positive cells as well as to the surro...

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Detalles Bibliográficos
Autores principales: Chung, Seung Woo, Choi, Jeong Uk, Cho, Young Seok, Kim, Ha Rin, Won, Tae Hyung, Dimitrion, Peter, Jeon, Ok‐Cheol, Kim, Seong Who, Kim, In‐San, Kim, Sang Yoon, Byun, Youngro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051143/
https://www.ncbi.nlm.nih.gov/pubmed/30027061
http://dx.doi.org/10.1002/advs.201800368

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