A comprehensive and perspective view of oncoprotein SET in cancer

SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of S...

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Detalles Bibliográficos
Autores principales: Bayarkhangai, Buuvee, Noureldin, Suzan, Yu, Liting, Zhao, Na, Gu, Yaru, Xu, Hanmei, Guo, Changying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051184/
https://www.ncbi.nlm.nih.gov/pubmed/29749127
http://dx.doi.org/10.1002/cam4.1526
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author Bayarkhangai, Buuvee
Noureldin, Suzan
Yu, Liting
Zhao, Na
Gu, Yaru
Xu, Hanmei
Guo, Changying
author_facet Bayarkhangai, Buuvee
Noureldin, Suzan
Yu, Liting
Zhao, Na
Gu, Yaru
Xu, Hanmei
Guo, Changying
author_sort Bayarkhangai, Buuvee
collection PubMed
description SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of SET correlate with cancer occurrence, metastasis, and prognosis. Therefore, the SET protein is regarded as a potential target for cancer therapy and several inhibitors are being developed for clinical use. Herein, we comprehensively review the physiological and pathological functions of SET as well as its structure‐function relationship. Additionally, the regulatory mechanisms of SET at both transcriptional and posttranslational levels are also discussed.
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spelling pubmed-60511842018-07-20 A comprehensive and perspective view of oncoprotein SET in cancer Bayarkhangai, Buuvee Noureldin, Suzan Yu, Liting Zhao, Na Gu, Yaru Xu, Hanmei Guo, Changying Cancer Med Cancer Biology SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of SET correlate with cancer occurrence, metastasis, and prognosis. Therefore, the SET protein is regarded as a potential target for cancer therapy and several inhibitors are being developed for clinical use. Herein, we comprehensively review the physiological and pathological functions of SET as well as its structure‐function relationship. Additionally, the regulatory mechanisms of SET at both transcriptional and posttranslational levels are also discussed. John Wiley and Sons Inc. 2018-05-10 /pmc/articles/PMC6051184/ /pubmed/29749127 http://dx.doi.org/10.1002/cam4.1526 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Bayarkhangai, Buuvee
Noureldin, Suzan
Yu, Liting
Zhao, Na
Gu, Yaru
Xu, Hanmei
Guo, Changying
A comprehensive and perspective view of oncoprotein SET in cancer
title A comprehensive and perspective view of oncoprotein SET in cancer
title_full A comprehensive and perspective view of oncoprotein SET in cancer
title_fullStr A comprehensive and perspective view of oncoprotein SET in cancer
title_full_unstemmed A comprehensive and perspective view of oncoprotein SET in cancer
title_short A comprehensive and perspective view of oncoprotein SET in cancer
title_sort comprehensive and perspective view of oncoprotein set in cancer
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051184/
https://www.ncbi.nlm.nih.gov/pubmed/29749127
http://dx.doi.org/10.1002/cam4.1526
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