Pathway analysis of genetic variants in folate‐mediated one‐carbon metabolism‐related genes and survival in a prospectively followed cohort of colorectal cancer patients

Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal cancer (CRC) treatment. A comprehensive assessment of polymorphisms i...

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Detalles Bibliográficos
Autores principales: Ose, Jennifer, Botma, Akke, Balavarca, Yesilda, Buck, Katharina, Scherer, Dominique, Habermann, Nina, Beyerle, Jolantha, Pfütze, Katrin, Seibold, Petra, Kap, Elisabeth J., Benner, Axel, Jansen, Lina, Butterbach, Katja, Hoffmeister, Michael, Brenner, Hermann, Ulrich, Alexis, Schneider, Martin, Chang‐Claude, Jenny, Burwinkel, Barbara, Ulrich, Cornelia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051204/
https://www.ncbi.nlm.nih.gov/pubmed/29845757
http://dx.doi.org/10.1002/cam4.1407

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