DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication

Complex‐shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics‐based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has shown great potential for creating highly 3D‐shaped particles in a high‐throughput manner, but the particle dimensions are mainly at the millimeter scale. Here, a next generation optofluidic fabrication process is presented that utilizes on‐the‐fly fabricated multiscale fluidic channels producing customized sub‐100 µm 3D‐shaped microparticles. This flexible design scheme offers a user‐friendly platform for rapid prototyping of new 3D particle shapes, providing greater potential for creating impactful engineered microparticles.