ATF4 Regulates CD4(+) T Cell Immune Responses through Metabolic Reprogramming

T cells are strongly regulated by oxidizing environments and amino acid restriction. How T cells reprogram metabolism to adapt to these extracellular stress situations is not well understood. Here, we show that oxidizing environments and amino acid starvation induce ATF4 in CD4(+) T cells. We also d...

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Detalles Bibliográficos
Autores principales: Yang, Xi, Xia, Rui, Yue, Cuihua, Zhai, Wensi, Du, Wenwen, Yang, Qianting, Cao, Huiling, Chen, Xiaojuan, Obando, Danielle, Zhu, Yibei, Chen, Xinchun, Chen, Jane-Jane, Piganelli, Jon, Wipf, Peter, Jiang, Yu, Xiao, Guozhi, Wu, Changping, Jiang, Jingting, Lu, Binfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051420/
https://www.ncbi.nlm.nih.gov/pubmed/29742431
http://dx.doi.org/10.1016/j.celrep.2018.04.032

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