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Outcome of patients with acute bacterial meningitis in a teaching hospital in Ethiopia: A prospective study

BACKGROUND: The mortality and neurologic sequelae associated with acute bacterial meningitis (ABM) remain high despite advances in medical care. The main aim of this study was to evaluate short-term outcome in patients treated as bacterial meningitis at a teaching hospital in Ethiopia to identify fa...

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Autores principales: Gudina, Esayas Kebede, Tesfaye, Markos, Wieser, Andreas, Pfister, Hans-Walter, Klein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051621/
https://www.ncbi.nlm.nih.gov/pubmed/30020952
http://dx.doi.org/10.1371/journal.pone.0200067
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author Gudina, Esayas Kebede
Tesfaye, Markos
Wieser, Andreas
Pfister, Hans-Walter
Klein, Matthias
author_facet Gudina, Esayas Kebede
Tesfaye, Markos
Wieser, Andreas
Pfister, Hans-Walter
Klein, Matthias
author_sort Gudina, Esayas Kebede
collection PubMed
description BACKGROUND: The mortality and neurologic sequelae associated with acute bacterial meningitis (ABM) remain high despite advances in medical care. The main aim of this study was to evaluate short-term outcome in patients treated as bacterial meningitis at a teaching hospital in Ethiopia to identify factors that could be focused on to improve outcome in this setting. METHODS: A hospital based longitudinal study was conducted at Jimma University Hospital in southwest Ethiopia from March 1, 2013 to December 31, 2015. Participants of this study were patients of age 18 years and older who were treated as confirmed or possible cases of ABM. Patients were followed throughout their hospital stay for change in their clinical course and predefined end points. A multivariable analysis was done to identify factors associated with unfavorable outcomes. RESULT: 90 patients admitted with diagnosis of acute bacterial meningitis were included in the study; cerebrospinal fluid was analysed for 85 (94.4%) of them. Causative bacteria were isolated in 26 (28.9%) patients only; most of these isolates (84.6%) were either Streptococcus pneumoniae or Neisseria meningitidis. Patients managed as cases of ABM at the hospital suffered from a high rate of unfavorable outcome (36.7%) and an overall mortality rate of 22.2%. Impaired level of consciousness (AOR = 0.766, 95% CI = 0.589–0.995), dexamethasone therapy (AOR = 4.676, 95% CI = 1.12–19.50) and fever persisting after two days of admission (AOR = 24.226, 95% CI = 5.24–111.96) were found to be independently associated with unfavorable outcome. CONCLUSION: Outcome in patients treated for ABM at the hospital was found to be poor. Impaired mentation, treatment with adjunctive dexamethasone and persistent fever were found to be associated with poor outcome. Thus, development of clinical guidelines for treatment of ABM that suit the local context is essential to improve patient management and outcome.
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spelling pubmed-60516212018-07-27 Outcome of patients with acute bacterial meningitis in a teaching hospital in Ethiopia: A prospective study Gudina, Esayas Kebede Tesfaye, Markos Wieser, Andreas Pfister, Hans-Walter Klein, Matthias PLoS One Research Article BACKGROUND: The mortality and neurologic sequelae associated with acute bacterial meningitis (ABM) remain high despite advances in medical care. The main aim of this study was to evaluate short-term outcome in patients treated as bacterial meningitis at a teaching hospital in Ethiopia to identify factors that could be focused on to improve outcome in this setting. METHODS: A hospital based longitudinal study was conducted at Jimma University Hospital in southwest Ethiopia from March 1, 2013 to December 31, 2015. Participants of this study were patients of age 18 years and older who were treated as confirmed or possible cases of ABM. Patients were followed throughout their hospital stay for change in their clinical course and predefined end points. A multivariable analysis was done to identify factors associated with unfavorable outcomes. RESULT: 90 patients admitted with diagnosis of acute bacterial meningitis were included in the study; cerebrospinal fluid was analysed for 85 (94.4%) of them. Causative bacteria were isolated in 26 (28.9%) patients only; most of these isolates (84.6%) were either Streptococcus pneumoniae or Neisseria meningitidis. Patients managed as cases of ABM at the hospital suffered from a high rate of unfavorable outcome (36.7%) and an overall mortality rate of 22.2%. Impaired level of consciousness (AOR = 0.766, 95% CI = 0.589–0.995), dexamethasone therapy (AOR = 4.676, 95% CI = 1.12–19.50) and fever persisting after two days of admission (AOR = 24.226, 95% CI = 5.24–111.96) were found to be independently associated with unfavorable outcome. CONCLUSION: Outcome in patients treated for ABM at the hospital was found to be poor. Impaired mentation, treatment with adjunctive dexamethasone and persistent fever were found to be associated with poor outcome. Thus, development of clinical guidelines for treatment of ABM that suit the local context is essential to improve patient management and outcome. Public Library of Science 2018-07-18 /pmc/articles/PMC6051621/ /pubmed/30020952 http://dx.doi.org/10.1371/journal.pone.0200067 Text en © 2018 Gudina et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gudina, Esayas Kebede
Tesfaye, Markos
Wieser, Andreas
Pfister, Hans-Walter
Klein, Matthias
Outcome of patients with acute bacterial meningitis in a teaching hospital in Ethiopia: A prospective study
title Outcome of patients with acute bacterial meningitis in a teaching hospital in Ethiopia: A prospective study
title_full Outcome of patients with acute bacterial meningitis in a teaching hospital in Ethiopia: A prospective study
title_fullStr Outcome of patients with acute bacterial meningitis in a teaching hospital in Ethiopia: A prospective study
title_full_unstemmed Outcome of patients with acute bacterial meningitis in a teaching hospital in Ethiopia: A prospective study
title_short Outcome of patients with acute bacterial meningitis in a teaching hospital in Ethiopia: A prospective study
title_sort outcome of patients with acute bacterial meningitis in a teaching hospital in ethiopia: a prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051621/
https://www.ncbi.nlm.nih.gov/pubmed/30020952
http://dx.doi.org/10.1371/journal.pone.0200067
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