Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CC(hum) mice

Platelet-derived growth factor CC (PDGF-CC) is important during foetal development but also in pathogenesis of neurologic diseases, cancer and fibrosis. We have previously demonstrated that blocking the PDGF-CC/PDGF receptor alpha (PDGFRα) axis resulted in reduction of stroke volume and cerebrovascu...

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Detalles Bibliográficos
Autores principales: Zeitelhofer, Manuel, Li, Hong, Adzemovic, Milena Z., Nilsson, Ingrid, Muhl, Lars, Scott, Andrew M., Eriksson, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051635/
https://www.ncbi.nlm.nih.gov/pubmed/30021009
http://dx.doi.org/10.1371/journal.pone.0200649

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