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Ubiquitination of alpha-synuclein filaments by Nedd4 ligases

Alpha-synuclein can form beta-sheet filaments, the accumulation of which plays a key role in the development of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. It has previously been shown that alpha-synuclein is a substrate for the HECT domain-containing ubiquitin ligase...

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Detalles Bibliográficos
Autores principales:	Mund, Thomas, Masuda-Suzukake, Masami, Goedert, Michel, Pelham, Hugh R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051637/ https://www.ncbi.nlm.nih.gov/pubmed/30021006 http://dx.doi.org/10.1371/journal.pone.0200763

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