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Increased expression of p16 in both oral and genital lichen planus

BACKGROUND: Lichen Planus, LP, is an inflammatory disease of possible autoimmune origin affecting mainly oral and genital mucosa and skin. According to the WHO oral LP is considered a potentially malignant disorders. The p16 tumour suppressor protein can act as an inhibitor of cyclin dependent kinas...

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Autores principales: Danielsson, Karin, Olah, Joakim, Zohori-Zangeneh, Reza, Nylander, Elisabet, Ebrahimi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051687/
https://www.ncbi.nlm.nih.gov/pubmed/29924765
http://dx.doi.org/10.4317/medoral.22432
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author Danielsson, Karin
Olah, Joakim
Zohori-Zangeneh, Reza
Nylander, Elisabet
Ebrahimi, Majid
author_facet Danielsson, Karin
Olah, Joakim
Zohori-Zangeneh, Reza
Nylander, Elisabet
Ebrahimi, Majid
author_sort Danielsson, Karin
collection PubMed
description BACKGROUND: Lichen Planus, LP, is an inflammatory disease of possible autoimmune origin affecting mainly oral and genital mucosa and skin. According to the WHO oral LP is considered a potentially malignant disorders. The p16 tumour suppressor protein can act as an inhibitor of cyclin dependent kinases 4 and 6 and thus down regulate cell cycle progression. Since the discovery of p16 several studies have evaluated its expression in various forms of human cancers. The aim of this study was to evaluate and compare the expression of p16 in oral and genital LP and corresponding healthy mucosa. MATERIAL AND METHODS: A total of 76 cases of oral LP (OLP), 34 cases of genital LP (GLP), 12 cases of healthy oral and 9 cases of healthy genital mucosa were analysed by the use of immunohistochemistry. RESULTS: Data showed p16 to be highly expressed in both oral and genital LP, higher than in oral (p=0.000), and genital controls (p=0.002). CONCLUSIONS: Results suggest that the over-expression of p16 seen in LP play a part in the histopathology of the disease. Key words:p16, inflammation, oral, genital, lichen planus, malignant risk.
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spelling pubmed-60516872018-07-23 Increased expression of p16 in both oral and genital lichen planus Danielsson, Karin Olah, Joakim Zohori-Zangeneh, Reza Nylander, Elisabet Ebrahimi, Majid Med Oral Patol Oral Cir Bucal Research BACKGROUND: Lichen Planus, LP, is an inflammatory disease of possible autoimmune origin affecting mainly oral and genital mucosa and skin. According to the WHO oral LP is considered a potentially malignant disorders. The p16 tumour suppressor protein can act as an inhibitor of cyclin dependent kinases 4 and 6 and thus down regulate cell cycle progression. Since the discovery of p16 several studies have evaluated its expression in various forms of human cancers. The aim of this study was to evaluate and compare the expression of p16 in oral and genital LP and corresponding healthy mucosa. MATERIAL AND METHODS: A total of 76 cases of oral LP (OLP), 34 cases of genital LP (GLP), 12 cases of healthy oral and 9 cases of healthy genital mucosa were analysed by the use of immunohistochemistry. RESULTS: Data showed p16 to be highly expressed in both oral and genital LP, higher than in oral (p=0.000), and genital controls (p=0.002). CONCLUSIONS: Results suggest that the over-expression of p16 seen in LP play a part in the histopathology of the disease. Key words:p16, inflammation, oral, genital, lichen planus, malignant risk. Medicina Oral S.L. 2018-07 2018-06-21 /pmc/articles/PMC6051687/ /pubmed/29924765 http://dx.doi.org/10.4317/medoral.22432 Text en Copyright: © 2018 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Danielsson, Karin
Olah, Joakim
Zohori-Zangeneh, Reza
Nylander, Elisabet
Ebrahimi, Majid
Increased expression of p16 in both oral and genital lichen planus
title Increased expression of p16 in both oral and genital lichen planus
title_full Increased expression of p16 in both oral and genital lichen planus
title_fullStr Increased expression of p16 in both oral and genital lichen planus
title_full_unstemmed Increased expression of p16 in both oral and genital lichen planus
title_short Increased expression of p16 in both oral and genital lichen planus
title_sort increased expression of p16 in both oral and genital lichen planus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051687/
https://www.ncbi.nlm.nih.gov/pubmed/29924765
http://dx.doi.org/10.4317/medoral.22432
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