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Steric interference from intrinsically disordered regions controls dynamin-related protein 1 self-assembly during mitochondrial fission

The self-assembling, mechanoenzymatic dynamin superfamily GTPase, dynamin-related protein 1 (Drp1), catalyzes mitochondrial and peroxisomal fission. Distinct intrinsically disordered regions (IDRs) in Drp1 substitute for the canonical pleckstrin homology (PH) domain and proline-rich domain (PRD) of...

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Detalles Bibliográficos
Autores principales:	Lu, Bin, Kennedy, Bridget, Clinton, Ryan W., Wang, Emily Jue, McHugh, Daniel, Stepanyants, Natalia, Macdonald, Patrick J., Mears, Jason A., Qi, Xin, Ramachandran, Rajesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051998/ https://www.ncbi.nlm.nih.gov/pubmed/30022112 http://dx.doi.org/10.1038/s41598-018-29001-9

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