Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by (31)P-MRS

Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD(+)/NADH ratio in the resting b...

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Autores principales: Xin, Lijing, Ipek, Özlem, Beaumont, Maurice, Shevlyakova, Maya, Christinat, Nicolas, Masoodi, Mojgan, Greenberg, Norman, Gruetter, Rolf, Cuenoud, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Nutrition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052097/
https://www.ncbi.nlm.nih.gov/pubmed/30050907
http://dx.doi.org/10.3389/fnut.2018.00062
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author Xin, Lijing
Ipek, Özlem
Beaumont, Maurice
Shevlyakova, Maya
Christinat, Nicolas
Masoodi, Mojgan
Greenberg, Norman
Gruetter, Rolf
Cuenoud, Bernard
author_facet Xin, Lijing
Ipek, Özlem
Beaumont, Maurice
Shevlyakova, Maya
Christinat, Nicolas
Masoodi, Mojgan
Greenberg, Norman
Gruetter, Rolf
Cuenoud, Bernard
author_sort Xin, Lijing
collection PubMed
description Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD(+)/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health.
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spelling pubmed-60520972018-07-26 Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by (31)P-MRS Xin, Lijing Ipek, Özlem Beaumont, Maurice Shevlyakova, Maya Christinat, Nicolas Masoodi, Mojgan Greenberg, Norman Gruetter, Rolf Cuenoud, Bernard Front Nutr Nutrition Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD(+)/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health. Frontiers Media S.A. 2018-07-12 /pmc/articles/PMC6052097/ /pubmed/30050907 http://dx.doi.org/10.3389/fnut.2018.00062 Text en Copyright © 2018 Xin, Ipek, Beaumont, Shevlyakova, Christinat, Masoodi, Greenberg, Gruetter and Cuenoud. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Xin, Lijing
Ipek, Özlem
Beaumont, Maurice
Shevlyakova, Maya
Christinat, Nicolas
Masoodi, Mojgan
Greenberg, Norman
Gruetter, Rolf
Cuenoud, Bernard
Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by (31)P-MRS
title Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by (31)P-MRS
title_full Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by (31)P-MRS
title_fullStr Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by (31)P-MRS
title_full_unstemmed Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by (31)P-MRS
title_short Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by (31)P-MRS
title_sort nutritional ketosis increases nad(+)/nadh ratio in healthy human brain: an in vivo study by (31)p-mrs
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052097/
https://www.ncbi.nlm.nih.gov/pubmed/30050907
http://dx.doi.org/10.3389/fnut.2018.00062
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