mTORC1 Activation by Loss of Tsc1 in Myelinating Glia Causes Downregulation of Quaking and Neurofascin 155 Leading to Paranodal Domain Disorganization

Mutations in human tuberous sclerosis complex (TSC) genes TSC1 and TSC2 are the leading causes of developmental brain abnormalities and large tumors in other tissues. Murine Tsc1/2 have been shown to negatively regulate the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway in most t...

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Detalles Bibliográficos
Autores principales: Shi, Qian, Saifetiarova, Julia, Taylor, Anna Marie, Bhat, Manzoor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052123/
https://www.ncbi.nlm.nih.gov/pubmed/30050412
http://dx.doi.org/10.3389/fncel.2018.00201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052123/
https://www.ncbi.nlm.nih.gov/pubmed/30050412
http://dx.doi.org/10.3389/fncel.2018.00201

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