Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity

Hematopoietic stem cells (HSCs) are used clinically in bone marrow (BM) transplantation due to their unique ability to reform the entire hematopoietic system. Recently, we reported that HSCs are highly sensitive to valine, one of the three branched-chain amino acids (BCAAs) in addition to isoleucine...

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Detalles Bibliográficos
Autores principales: Wilkinson, Adam C., Morita, Maiko, Nakauchia, Hiromitsu, Yamazaki, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Inc 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052250/
https://www.ncbi.nlm.nih.gov/pubmed/29705267
http://dx.doi.org/10.1016/j.exphem.2018.04.004

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