Discrimination of three mutational events that result in a disruption of the R122 primary autolysis site of the human cationic trypsinogen (PRSS1) by denaturing high performance liquid chromatography

BACKGROUND: R122, the primary autolysis site of the human cationic trypsinogen (PRSS1), constitutes an important "self-destruct" or "fail-safe" defensive mechanism against premature trypsin activation within the pancreas. Disruption of this site by a missense mutation, R122H, was...

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Detalles Bibliográficos
Autores principales: Le Maréchal, Cedric, Chen, Jian-Min, Quéré, Isabelle, Raguénès, Odile, Férec, Claude, Auroux, Jean
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC60523/
https://www.ncbi.nlm.nih.gov/pubmed/11734061
http://dx.doi.org/10.1186/1471-2156-2-19

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