Lifelong reduction in complex IV induces tissue‐specific metabolic effects but does not reduce lifespan or healthspan in mice

Loss of SURF1, a Complex IV assembly protein, was reported to increase lifespan in mice despite dramatically lower cytochrome oxidase (COX) activity. Consistent with this, our previous studies found advantageous changes in metabolism (reduced adiposity, increased insulin sensitivity, and mitochondri...

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Detalles Bibliográficos
Autores principales: Deepa, Sathyaseelan S., Pharaoh, Gavin, Kinter, Michael, Diaz, Vivian, Fok, Wilson C., Riddle, Kaitlyn, Pulliam, Daniel, Hill, Shauna, Fischer, Kathleen E., Soto, Vanessa, Georgescu, Constantin, Wren, Jonathan D., Viscomi, Carlo, Richardson, Arlan, Van Remmen, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052393/
https://www.ncbi.nlm.nih.gov/pubmed/29696791
http://dx.doi.org/10.1111/acel.12769

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