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3D printed porous β-Ca(2)SiO(4) scaffolds derived from preceramic resin and their physicochemical and biological properties

Silicate bioceramic scaffolds are of great interest in bone tissue engineering, but the fabrication of silicate bioceramic scaffolds with complex geometries is still challenging. In this study, three-dimensional (3D) porous β-Ca(2)SiO(4) scaffolds have been successfully fabricated from preceramic re...

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Detalles Bibliográficos
Autores principales: Fu, Shengyang, Liu, Wei, Liu, Shiwei, Zhao, Shichang, Zhu, Yufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052414/
https://www.ncbi.nlm.nih.gov/pubmed/30034559
http://dx.doi.org/10.1080/14686996.2018.1471653
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author Fu, Shengyang
Liu, Wei
Liu, Shiwei
Zhao, Shichang
Zhu, Yufang
author_facet Fu, Shengyang
Liu, Wei
Liu, Shiwei
Zhao, Shichang
Zhu, Yufang
author_sort Fu, Shengyang
collection PubMed
description Silicate bioceramic scaffolds are of great interest in bone tissue engineering, but the fabrication of silicate bioceramic scaffolds with complex geometries is still challenging. In this study, three-dimensional (3D) porous β-Ca(2)SiO(4) scaffolds have been successfully fabricated from preceramic resin loaded with CaCO(3) active filler by 3D printing. The fabricated β-Ca(2)SiO(4) scaffolds had uniform interconnected macropores (ca. 400 μm), high porosity (>78%), enhanced mechanical strength (ca. 5.2 MPa), and excellent apatite mineralization ability. Importantly, the results showed that the increase of sintering temperature significantly enhanced the compressive strength and the scaffolds sintered at higher sintering temperature stimulated the adhesion, proliferation, alkaline phosphatase activity, and osteogenic-related gene expression of rat bone mesenchymal stem cells. Therefore, the 3D printed β-Ca(2)SiO(4) scaffolds derived from preceramic resin and CaCO(3) active fillers would be promising candidates for bone tissue engineering.
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spelling pubmed-60524142018-07-20 3D printed porous β-Ca(2)SiO(4) scaffolds derived from preceramic resin and their physicochemical and biological properties Fu, Shengyang Liu, Wei Liu, Shiwei Zhao, Shichang Zhu, Yufang Sci Technol Adv Mater Bio-Inspired and Biomedical Materials Silicate bioceramic scaffolds are of great interest in bone tissue engineering, but the fabrication of silicate bioceramic scaffolds with complex geometries is still challenging. In this study, three-dimensional (3D) porous β-Ca(2)SiO(4) scaffolds have been successfully fabricated from preceramic resin loaded with CaCO(3) active filler by 3D printing. The fabricated β-Ca(2)SiO(4) scaffolds had uniform interconnected macropores (ca. 400 μm), high porosity (>78%), enhanced mechanical strength (ca. 5.2 MPa), and excellent apatite mineralization ability. Importantly, the results showed that the increase of sintering temperature significantly enhanced the compressive strength and the scaffolds sintered at higher sintering temperature stimulated the adhesion, proliferation, alkaline phosphatase activity, and osteogenic-related gene expression of rat bone mesenchymal stem cells. Therefore, the 3D printed β-Ca(2)SiO(4) scaffolds derived from preceramic resin and CaCO(3) active fillers would be promising candidates for bone tissue engineering. Taylor & Francis 2018-07-16 /pmc/articles/PMC6052414/ /pubmed/30034559 http://dx.doi.org/10.1080/14686996.2018.1471653 Text en © 2018 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Bio-Inspired and Biomedical Materials
Fu, Shengyang
Liu, Wei
Liu, Shiwei
Zhao, Shichang
Zhu, Yufang
3D printed porous β-Ca(2)SiO(4) scaffolds derived from preceramic resin and their physicochemical and biological properties
title 3D printed porous β-Ca(2)SiO(4) scaffolds derived from preceramic resin and their physicochemical and biological properties
title_full 3D printed porous β-Ca(2)SiO(4) scaffolds derived from preceramic resin and their physicochemical and biological properties
title_fullStr 3D printed porous β-Ca(2)SiO(4) scaffolds derived from preceramic resin and their physicochemical and biological properties
title_full_unstemmed 3D printed porous β-Ca(2)SiO(4) scaffolds derived from preceramic resin and their physicochemical and biological properties
title_short 3D printed porous β-Ca(2)SiO(4) scaffolds derived from preceramic resin and their physicochemical and biological properties
title_sort 3d printed porous β-ca(2)sio(4) scaffolds derived from preceramic resin and their physicochemical and biological properties
topic Bio-Inspired and Biomedical Materials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052414/
https://www.ncbi.nlm.nih.gov/pubmed/30034559
http://dx.doi.org/10.1080/14686996.2018.1471653
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