Expression of p16(INK) (4a) is a biomarker of chondrocyte aging but does not cause osteoarthritis

Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing pro‐inflammatory molecules known as the senescence‐associated secretory phenotype (SASP). The senescence biomarker p16 (INK) (4a) is a potent inhibitor of the cel...

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Detalles Bibliográficos
Autores principales: Diekman, Brian O., Sessions, Garrett A., Collins, John A., Knecht, Anne K., Strum, Susan L., Mitin, Natalia K., Carlson, Cathy S., Loeser, Richard F., Sharpless, Norman E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052464/
https://www.ncbi.nlm.nih.gov/pubmed/29744983
http://dx.doi.org/10.1111/acel.12771

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