Mice with reduced expression of the telomere‐associated protein Ft1 develop p53‐sensitive progeroid traits

Human AKTIP and mouse Ft1 are orthologous ubiquitin E2 variant proteins involved in telomere maintenance and DNA replication. AKTIP also interacts with A‐ and B‐type lamins. These features suggest that Ft1 may be implicated in aging regulatory pathways. Here, we show that cells derived from hypomorp...

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Detalles Bibliográficos
Autores principales: La Torre, Mattia, Merigliano, Chiara, Burla, Romina, Mottini, Carla, Zanetti, Giorgia, Del Giudice, Simona, Carcuro, Mariateresa, Virdia, Ilaria, Bucciarelli, Elisabetta, Manni, Isabella, Vinciguerra, Gianluca Rampioni, Piaggio, Giulia, Riminucci, Mara, Cumano, Ana, Bartolazzi, Armando, Vernì, Fiammetta, Soddu, Silvia, Gatti, Maurizio, Saggio, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052474/
https://www.ncbi.nlm.nih.gov/pubmed/29635765
http://dx.doi.org/10.1111/acel.12730

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