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Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru

BACKGROUND: Gestational diabetes mellitus (GDM) is a global public health concern with potential implications for the health of a mother and her offspring. However, data on the prevalence and risk factors of GDM in Latin America are scarce. The study was designed to estimate the prevalence of GDM an...

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Autores principales: Larrabure-Torrealva, Gloria T., Martinez, Stephanie, Luque-Fernandez, Miguel Angel, Sanchez, Sixto E., Mascaro, Pedro A., Ingar, Hugo, Castillo, Walter, Zumaeta, Rina, Grande, Mirtha, Motta, Vicky, Pacora, Percy, Gelaye, Bizu, Williams, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052534/
https://www.ncbi.nlm.nih.gov/pubmed/30021539
http://dx.doi.org/10.1186/s12884-018-1904-0
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author Larrabure-Torrealva, Gloria T.
Martinez, Stephanie
Luque-Fernandez, Miguel Angel
Sanchez, Sixto E.
Mascaro, Pedro A.
Ingar, Hugo
Castillo, Walter
Zumaeta, Rina
Grande, Mirtha
Motta, Vicky
Pacora, Percy
Gelaye, Bizu
Williams, Michelle A.
author_facet Larrabure-Torrealva, Gloria T.
Martinez, Stephanie
Luque-Fernandez, Miguel Angel
Sanchez, Sixto E.
Mascaro, Pedro A.
Ingar, Hugo
Castillo, Walter
Zumaeta, Rina
Grande, Mirtha
Motta, Vicky
Pacora, Percy
Gelaye, Bizu
Williams, Michelle A.
author_sort Larrabure-Torrealva, Gloria T.
collection PubMed
description BACKGROUND: Gestational diabetes mellitus (GDM) is a global public health concern with potential implications for the health of a mother and her offspring. However, data on the prevalence and risk factors of GDM in Latin America are scarce. The study was designed to estimate the prevalence of GDM and identify maternal risk factors among Peruvian women. METHODS: A cross-sectional study was conducted among 1300 pregnant women attending a prenatal clinic in Lima, Peru. GDM was diagnosed using an Oral Glucose Tolerance Test (OGTT) performed between 24 and 28 gestational weeks using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Depression status was assessed using the Patient Health Questionnaire-9. Multivariate logistic regression models were used to identify risk factors of GDM. RESULTS: Approximately 16% of pregnant women were diagnosed with GDM. The prevalence of obesity and depression were 24.4 and 10.6%, respectively. After adjusting for confounders, mid-pregnancy obesity was associated with a 1.64-fold increased odds of GDM (OR: 1.64; 95% CI: 1.03–2.61). Participants with a family history of diabetes had a 1.5-fold increased odds of developing GDM (OR: 1.51, 95% CI: 1.10–2.07) as compared to women without this family history. Depression was associated with a 1.54-fold increased odds of GDM (OR: 1.54; 95% CI:1.09–2.17). CONCLUSIONS: GDM is highly prevalent and was associated with maternal obesity, family history of diabetes and antepartum depression among Peruvian women. Intervention programs aimed at early diagnoses and management of GDM need to take maternal obesity, family history of diabetes and antepartum depression into account. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12884-018-1904-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-60525342018-07-20 Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru Larrabure-Torrealva, Gloria T. Martinez, Stephanie Luque-Fernandez, Miguel Angel Sanchez, Sixto E. Mascaro, Pedro A. Ingar, Hugo Castillo, Walter Zumaeta, Rina Grande, Mirtha Motta, Vicky Pacora, Percy Gelaye, Bizu Williams, Michelle A. BMC Pregnancy Childbirth Research Article BACKGROUND: Gestational diabetes mellitus (GDM) is a global public health concern with potential implications for the health of a mother and her offspring. However, data on the prevalence and risk factors of GDM in Latin America are scarce. The study was designed to estimate the prevalence of GDM and identify maternal risk factors among Peruvian women. METHODS: A cross-sectional study was conducted among 1300 pregnant women attending a prenatal clinic in Lima, Peru. GDM was diagnosed using an Oral Glucose Tolerance Test (OGTT) performed between 24 and 28 gestational weeks using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Depression status was assessed using the Patient Health Questionnaire-9. Multivariate logistic regression models were used to identify risk factors of GDM. RESULTS: Approximately 16% of pregnant women were diagnosed with GDM. The prevalence of obesity and depression were 24.4 and 10.6%, respectively. After adjusting for confounders, mid-pregnancy obesity was associated with a 1.64-fold increased odds of GDM (OR: 1.64; 95% CI: 1.03–2.61). Participants with a family history of diabetes had a 1.5-fold increased odds of developing GDM (OR: 1.51, 95% CI: 1.10–2.07) as compared to women without this family history. Depression was associated with a 1.54-fold increased odds of GDM (OR: 1.54; 95% CI:1.09–2.17). CONCLUSIONS: GDM is highly prevalent and was associated with maternal obesity, family history of diabetes and antepartum depression among Peruvian women. Intervention programs aimed at early diagnoses and management of GDM need to take maternal obesity, family history of diabetes and antepartum depression into account. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12884-018-1904-0) contains supplementary material, which is available to authorized users. BioMed Central 2018-07-18 /pmc/articles/PMC6052534/ /pubmed/30021539 http://dx.doi.org/10.1186/s12884-018-1904-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Larrabure-Torrealva, Gloria T.
Martinez, Stephanie
Luque-Fernandez, Miguel Angel
Sanchez, Sixto E.
Mascaro, Pedro A.
Ingar, Hugo
Castillo, Walter
Zumaeta, Rina
Grande, Mirtha
Motta, Vicky
Pacora, Percy
Gelaye, Bizu
Williams, Michelle A.
Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru
title Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru
title_full Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru
title_fullStr Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru
title_full_unstemmed Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru
title_short Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru
title_sort prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in lima, peru
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052534/
https://www.ncbi.nlm.nih.gov/pubmed/30021539
http://dx.doi.org/10.1186/s12884-018-1904-0
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