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Discovery and validation of autosomal dominant Alzheimer’s disease mutations

BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline. Mutations in amyloid-β precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are the pathogenic cause of autosomal dominant AD (ADAD). However, pol...

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Detalles Bibliográficos
Autores principales:	Hsu, Simon, Gordon, Brian A., Hornbeck, Russ, Norton, Joanne B., Levitch, Denise, Louden, Adia, Ziegemeier, Ellen, Laforce, Robert, Chhatwal, Jasmeer, Day, Gregory S., McDade, Eric, Morris, John C., Fagan, Anne M., Benzinger, Tammie L. S., Goate, Alison M., Cruchaga, Carlos, Bateman, Randall J., Karch, Celeste M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052673/ https://www.ncbi.nlm.nih.gov/pubmed/30021643 http://dx.doi.org/10.1186/s13195-018-0392-9

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