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No evidence for human papillomavirus having a causal role in salivary gland tumors

BACKGROUND: Salivary gland malignancies are a very heterogeneous group of cancers, with histologically > 20 different subtypes, and prognosis varies greatly. Their etiology is unknown, however, a few small studies show presence of human papillomavirus (HPV) in some subtypes, although the evidence...

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Autores principales: Haeggblom, Linnea, Ursu, Ramona Gabriela, Mirzaie, Leila, Attoff, Tove, Gahm, Caroline, Nordenvall, Lalle Hammarstedt, Näsman, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052678/
https://www.ncbi.nlm.nih.gov/pubmed/30021645
http://dx.doi.org/10.1186/s13000-018-0721-0
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author Haeggblom, Linnea
Ursu, Ramona Gabriela
Mirzaie, Leila
Attoff, Tove
Gahm, Caroline
Nordenvall, Lalle Hammarstedt
Näsman, Anders
author_facet Haeggblom, Linnea
Ursu, Ramona Gabriela
Mirzaie, Leila
Attoff, Tove
Gahm, Caroline
Nordenvall, Lalle Hammarstedt
Näsman, Anders
author_sort Haeggblom, Linnea
collection PubMed
description BACKGROUND: Salivary gland malignancies are a very heterogeneous group of cancers, with histologically > 20 different subtypes, and prognosis varies greatly. Their etiology is unknown, however, a few small studies show presence of human papillomavirus (HPV) in some subtypes, although the evidence for HPV having a causal role is weak. The aim of this study was to investigate if HPV plays a causal role in the development of different parotid salivary gland tumor subtypes. METHODS: DNA was extracted from 107 parotid salivary gland formalin fixed paraffin embedded tumors and 10 corresponding metastases, and tested for 27 different HPV types using a multiplex bead based assay. HPV DNA positive tumors were stained for p16(INK4a) overexpression by immunohistochemistry. RESULTS: One of the 107 malignant parotid salivary gland tumors (0.93%) and its corresponding metastasis on the neck were positive for HPV16 DNA, and both also overexpressed p16(INK4a). The HPV positive primary tumor was a squamous cell carcinoma; neither mucoepidermoid nor adenoid cystic tumors were found HPV positive. CONCLUSIONS: In conclusion, HPV DNA analysis in a large number of malignant parotid salivary gland tumors, including 12 different subtypes, did not show any strong indications that tested HPV types have a causal role in the studied salivary gland tumor types. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13000-018-0721-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-60526782018-07-23 No evidence for human papillomavirus having a causal role in salivary gland tumors Haeggblom, Linnea Ursu, Ramona Gabriela Mirzaie, Leila Attoff, Tove Gahm, Caroline Nordenvall, Lalle Hammarstedt Näsman, Anders Diagn Pathol Research BACKGROUND: Salivary gland malignancies are a very heterogeneous group of cancers, with histologically > 20 different subtypes, and prognosis varies greatly. Their etiology is unknown, however, a few small studies show presence of human papillomavirus (HPV) in some subtypes, although the evidence for HPV having a causal role is weak. The aim of this study was to investigate if HPV plays a causal role in the development of different parotid salivary gland tumor subtypes. METHODS: DNA was extracted from 107 parotid salivary gland formalin fixed paraffin embedded tumors and 10 corresponding metastases, and tested for 27 different HPV types using a multiplex bead based assay. HPV DNA positive tumors were stained for p16(INK4a) overexpression by immunohistochemistry. RESULTS: One of the 107 malignant parotid salivary gland tumors (0.93%) and its corresponding metastasis on the neck were positive for HPV16 DNA, and both also overexpressed p16(INK4a). The HPV positive primary tumor was a squamous cell carcinoma; neither mucoepidermoid nor adenoid cystic tumors were found HPV positive. CONCLUSIONS: In conclusion, HPV DNA analysis in a large number of malignant parotid salivary gland tumors, including 12 different subtypes, did not show any strong indications that tested HPV types have a causal role in the studied salivary gland tumor types. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13000-018-0721-0) contains supplementary material, which is available to authorized users. BioMed Central 2018-07-18 /pmc/articles/PMC6052678/ /pubmed/30021645 http://dx.doi.org/10.1186/s13000-018-0721-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Haeggblom, Linnea
Ursu, Ramona Gabriela
Mirzaie, Leila
Attoff, Tove
Gahm, Caroline
Nordenvall, Lalle Hammarstedt
Näsman, Anders
No evidence for human papillomavirus having a causal role in salivary gland tumors
title No evidence for human papillomavirus having a causal role in salivary gland tumors
title_full No evidence for human papillomavirus having a causal role in salivary gland tumors
title_fullStr No evidence for human papillomavirus having a causal role in salivary gland tumors
title_full_unstemmed No evidence for human papillomavirus having a causal role in salivary gland tumors
title_short No evidence for human papillomavirus having a causal role in salivary gland tumors
title_sort no evidence for human papillomavirus having a causal role in salivary gland tumors
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052678/
https://www.ncbi.nlm.nih.gov/pubmed/30021645
http://dx.doi.org/10.1186/s13000-018-0721-0
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