Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

BACKGROUND: Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination. The scale of these costs is highly variable. Some, including resistance of Staphylococcus aureus to the clinically important antibiotic mupirocin, have been reported as being...

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Detalles Bibliográficos
Autores principales: Yokoyama, Maho, Stevens, Emily, Laabei, Maisem, Bacon, Leann, Heesom, Kate, Bayliss, Sion, Ooi, Nicola, O’Neill, Alex J., Murray, Ewan, Williams, Paul, Lubben, Anneke, Reeksting, Shaun, Meric, Guillaume, Pascoe, Ben, Sheppard, Samuel K., Recker, Mario, Hurst, Laurence D., Massey, Ruth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052701/
https://www.ncbi.nlm.nih.gov/pubmed/30021593
http://dx.doi.org/10.1186/s13059-018-1469-2

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