Cargando…

A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese

This paper describes 35 Pekingese dogs with a syndrome characterized by dyspnea, cyanosis, episodic syncope, soft pulmonary “velcro” crackles, pulmonary hypertension (PH), and computed tomography and radiographic changes consistent with pulmonary parenchymal disease. The medical data base was search...

Descripción completa

Detalles Bibliográficos
Autores principales: Köster, Liza S, Kirberger, Robert M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053043/
https://www.ncbi.nlm.nih.gov/pubmed/30050834
http://dx.doi.org/10.2147/VMRR.S92729
_version_ 1783340751621455872
author Köster, Liza S
Kirberger, Robert M
author_facet Köster, Liza S
Kirberger, Robert M
author_sort Köster, Liza S
collection PubMed
description This paper describes 35 Pekingese dogs with a syndrome characterized by dyspnea, cyanosis, episodic syncope, soft pulmonary “velcro” crackles, pulmonary hypertension (PH), and computed tomography and radiographic changes consistent with pulmonary parenchymal disease. The medical data base was searched with the criteria “Pekingese” and “syncope” or “dyspnea” or “tachypnea” or “pulmonary hypertension”, over a 36-month period. Inclusion criteria were echocardiographic changes consistent with noninvasive diagnosis of PH, either subjectively by B-mode or objectively by Doppler. Dogs were excluded (n=106) if there were insufficient or poor-quality radiographic or echocardiographic records or if diseases other than chronic pulmonary disease were found to be the etiology. The records of 35 dogs met these criteria and presented with a respiratory crises preceded by a history of chronic exercise intolerance and episodic syncope. The average age was 14.5 years (range: 7–19 years), with 21 males and 14 females. Most of the dogs had an interstitial lung pattern with radiographic evidence of right heart enlargement. There was a 77% (n=27) mortality and a median survival of 60 days (interquartile range: 9–210 days). This study highlights a cor pulmonale syndrome from PH due to chronic pulmonary parenchymal disease, with a grave prognosis, in middle-aged to geriatric population of Hong Kong Pekingese.
format Online
Article
Text
id pubmed-6053043
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-60530432018-07-26 A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese Köster, Liza S Kirberger, Robert M Vet Med (Auckl) Original Research This paper describes 35 Pekingese dogs with a syndrome characterized by dyspnea, cyanosis, episodic syncope, soft pulmonary “velcro” crackles, pulmonary hypertension (PH), and computed tomography and radiographic changes consistent with pulmonary parenchymal disease. The medical data base was searched with the criteria “Pekingese” and “syncope” or “dyspnea” or “tachypnea” or “pulmonary hypertension”, over a 36-month period. Inclusion criteria were echocardiographic changes consistent with noninvasive diagnosis of PH, either subjectively by B-mode or objectively by Doppler. Dogs were excluded (n=106) if there were insufficient or poor-quality radiographic or echocardiographic records or if diseases other than chronic pulmonary disease were found to be the etiology. The records of 35 dogs met these criteria and presented with a respiratory crises preceded by a history of chronic exercise intolerance and episodic syncope. The average age was 14.5 years (range: 7–19 years), with 21 males and 14 females. Most of the dogs had an interstitial lung pattern with radiographic evidence of right heart enlargement. There was a 77% (n=27) mortality and a median survival of 60 days (interquartile range: 9–210 days). This study highlights a cor pulmonale syndrome from PH due to chronic pulmonary parenchymal disease, with a grave prognosis, in middle-aged to geriatric population of Hong Kong Pekingese. Dove Medical Press 2016-02-23 /pmc/articles/PMC6053043/ /pubmed/30050834 http://dx.doi.org/10.2147/VMRR.S92729 Text en © 2016 Köster and Kirberger. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Köster, Liza S
Kirberger, Robert M
A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_full A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_fullStr A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_full_unstemmed A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_short A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_sort syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in pekingese
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053043/
https://www.ncbi.nlm.nih.gov/pubmed/30050834
http://dx.doi.org/10.2147/VMRR.S92729
work_keys_str_mv AT kosterlizas asyndromeofsevereidiopathicpulmonaryparenchymaldiseasewithpulmonaryhypertensioninpekingese
AT kirbergerrobertm asyndromeofsevereidiopathicpulmonaryparenchymaldiseasewithpulmonaryhypertensioninpekingese
AT kosterlizas syndromeofsevereidiopathicpulmonaryparenchymaldiseasewithpulmonaryhypertensioninpekingese
AT kirbergerrobertm syndromeofsevereidiopathicpulmonaryparenchymaldiseasewithpulmonaryhypertensioninpekingese