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Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow
Active contraction of the diaphragm and other inspiratory pump muscles during swallow create a negative thoracic pressure to improve the movement of the bolus (food/liquid) into the esophagus. We tested the hypothesis that dorsomedial medullary inspiratory neurons, including the nucleus tractus soli...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053168/ https://www.ncbi.nlm.nih.gov/pubmed/30024913 http://dx.doi.org/10.1371/journal.pone.0199903 |
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author | Pitts, Teresa Poliacek, Ivan Rose, Melanie J. Reed, Mitchell D. Condrey, Jillian A. Tsai, Hsiu-Wen Zhou, Guannan Davenport, Paul W. Bolser, Donald C. |
author_facet | Pitts, Teresa Poliacek, Ivan Rose, Melanie J. Reed, Mitchell D. Condrey, Jillian A. Tsai, Hsiu-Wen Zhou, Guannan Davenport, Paul W. Bolser, Donald C. |
author_sort | Pitts, Teresa |
collection | PubMed |
description | Active contraction of the diaphragm and other inspiratory pump muscles during swallow create a negative thoracic pressure to improve the movement of the bolus (food/liquid) into the esophagus. We tested the hypothesis that dorsomedial medullary inspiratory neurons, including the nucleus tractus solitarius (NTS, pre-motor to the phrenic) would be active during swallow induced by oral water infusion. We recorded neurons in the NTS and medial reticular formation in anesthetized spontaneously breathing cats, and induced swallow by injection of water into the oropharynx. Our results indicate that: 1) a majority of inspiratory cells in the dorsomedial medulla are active during swallow, 2) expiratory neurons are present in the medial reticular formation (deeper to the NTS) in unparalyzed cats and a majority of these cells decreased firing frequency during swallow. Our findings suggest that the dorsomedial medulla is a source of inspiratory motor drive during swallow and that a novel population of breathing-modulated neurons that also are modulated during swallowing exist in the medial reticular formation in unparalyzed animals. |
format | Online Article Text |
id | pubmed-6053168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-60531682018-07-27 Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow Pitts, Teresa Poliacek, Ivan Rose, Melanie J. Reed, Mitchell D. Condrey, Jillian A. Tsai, Hsiu-Wen Zhou, Guannan Davenport, Paul W. Bolser, Donald C. PLoS One Research Article Active contraction of the diaphragm and other inspiratory pump muscles during swallow create a negative thoracic pressure to improve the movement of the bolus (food/liquid) into the esophagus. We tested the hypothesis that dorsomedial medullary inspiratory neurons, including the nucleus tractus solitarius (NTS, pre-motor to the phrenic) would be active during swallow induced by oral water infusion. We recorded neurons in the NTS and medial reticular formation in anesthetized spontaneously breathing cats, and induced swallow by injection of water into the oropharynx. Our results indicate that: 1) a majority of inspiratory cells in the dorsomedial medulla are active during swallow, 2) expiratory neurons are present in the medial reticular formation (deeper to the NTS) in unparalyzed cats and a majority of these cells decreased firing frequency during swallow. Our findings suggest that the dorsomedial medulla is a source of inspiratory motor drive during swallow and that a novel population of breathing-modulated neurons that also are modulated during swallowing exist in the medial reticular formation in unparalyzed animals. Public Library of Science 2018-07-19 /pmc/articles/PMC6053168/ /pubmed/30024913 http://dx.doi.org/10.1371/journal.pone.0199903 Text en © 2018 Pitts et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Pitts, Teresa Poliacek, Ivan Rose, Melanie J. Reed, Mitchell D. Condrey, Jillian A. Tsai, Hsiu-Wen Zhou, Guannan Davenport, Paul W. Bolser, Donald C. Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow |
title | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow |
title_full | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow |
title_fullStr | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow |
title_full_unstemmed | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow |
title_short | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow |
title_sort | neurons in the dorsomedial medulla contribute to swallow pattern generation: evidence of inspiratory activity during swallow |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053168/ https://www.ncbi.nlm.nih.gov/pubmed/30024913 http://dx.doi.org/10.1371/journal.pone.0199903 |
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