PNPase knockout results in mtDNA loss and an altered metabolic gene expression program

Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders. To reveal role(s) for PNPase in mitochondria, we established PNPase knockout (PKO) systems by first shifting culture conditions to enable cell...

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Detalles Bibliográficos
Autores principales: Shimada, Eriko, Ahsan, Fasih M., Nili, Mahta, Huang, Dian, Atamdede, Sean, TeSlaa, Tara, Case, Dana, Yu, Xiang, Gregory, Brian D., Perrin, Benjamin J., Koehler, Carla M., Teitell, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053217/
https://www.ncbi.nlm.nih.gov/pubmed/30024931
http://dx.doi.org/10.1371/journal.pone.0200925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053217/
https://www.ncbi.nlm.nih.gov/pubmed/30024931
http://dx.doi.org/10.1371/journal.pone.0200925

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