Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus

The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus aureus, (p)ppGpp is synthesized by the long RSH (RelA/SpoT homolog) enzyme, Rel(Sau) or by one of the two short synthetases (RelP, RelQ). RSH...

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Detalles Bibliográficos
Autores principales: Gratani, Fabio Lino, Horvatek, Petra, Geiger, Tobias, Borisova, Marina, Mayer, Christoph, Grin, Iwan, Wagner, Samuel, Steinchen, Wieland, Bange, Gert, Velic, Ana, Maček, Boris, Wolz, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053245/
https://www.ncbi.nlm.nih.gov/pubmed/29985927
http://dx.doi.org/10.1371/journal.pgen.1007514

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