HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

CD4 and chemokine receptors mediate HIV-1 attachment and entry. They are, however, insufficient to explain the preferential viral infection of central memory T cells. Here, we identify L-selectin (CD62L) as a viral adhesion receptor on CD4(+) T cells. The binding of viral envelope glycans to L-selec...

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Detalles Bibliográficos
Autores principales: Kononchik, Joseph, Ireland, Joanna, Zou, Zhongcheng, Segura, Jason, Holzapfel, Genevieve, Chastain, Ashley, Wang, Ruipeng, Spencer, Matthew, He, Biao, Stutzman, Nicole, Kano, Daiji, Arthos, James, Fischer, Elizabeth, Chun, Tae-Wook, Moir, Susan, Sun, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053365/
https://www.ncbi.nlm.nih.gov/pubmed/30026537
http://dx.doi.org/10.1038/s41467-018-05197-2

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