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Immune Regulation of Tissue Repair and Regeneration via miRNAs—New Therapeutic Target
The importance of immunity in tissue repair and regeneration is now evident. Thus, promoting tissue healing through immune modulation is a growing and promising field. Targeting microRNAs (miRNAs) is an appealing option since they regulate immunity through post-transcriptional gene fine-tuning in im...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053520/ https://www.ncbi.nlm.nih.gov/pubmed/30057898 http://dx.doi.org/10.3389/fbioe.2018.00098 |
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author | Piotto, Celeste Julier, Ziad Martino, Mikaël M. |
author_facet | Piotto, Celeste Julier, Ziad Martino, Mikaël M. |
author_sort | Piotto, Celeste |
collection | PubMed |
description | The importance of immunity in tissue repair and regeneration is now evident. Thus, promoting tissue healing through immune modulation is a growing and promising field. Targeting microRNAs (miRNAs) is an appealing option since they regulate immunity through post-transcriptional gene fine-tuning in immune cells. Indeed, miRNAs are involved in inflammation as well as in its resolution by controlling immune cell phenotypes and functions. In this review, we first discuss the immunoregulatory role of miRNAs during the restoration of tissue homeostasis after injury, focusing mainly on neutrophils, macrophages and T lymphocytes. As tissue examples, we present the immunoregulatory function of miRNAs during the repair and regeneration of the heart, skeletal muscles, skin and liver. Secondly, we discuss recent technological advances for designing therapeutic strategies which target miRNAs. Specifically, we highlight the possible use of miRNAs and anti-miRNAs for promoting tissue regeneration via modulation of the immune system. |
format | Online Article Text |
id | pubmed-6053520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60535202018-07-27 Immune Regulation of Tissue Repair and Regeneration via miRNAs—New Therapeutic Target Piotto, Celeste Julier, Ziad Martino, Mikaël M. Front Bioeng Biotechnol Bioengineering and Biotechnology The importance of immunity in tissue repair and regeneration is now evident. Thus, promoting tissue healing through immune modulation is a growing and promising field. Targeting microRNAs (miRNAs) is an appealing option since they regulate immunity through post-transcriptional gene fine-tuning in immune cells. Indeed, miRNAs are involved in inflammation as well as in its resolution by controlling immune cell phenotypes and functions. In this review, we first discuss the immunoregulatory role of miRNAs during the restoration of tissue homeostasis after injury, focusing mainly on neutrophils, macrophages and T lymphocytes. As tissue examples, we present the immunoregulatory function of miRNAs during the repair and regeneration of the heart, skeletal muscles, skin and liver. Secondly, we discuss recent technological advances for designing therapeutic strategies which target miRNAs. Specifically, we highlight the possible use of miRNAs and anti-miRNAs for promoting tissue regeneration via modulation of the immune system. Frontiers Media S.A. 2018-07-13 /pmc/articles/PMC6053520/ /pubmed/30057898 http://dx.doi.org/10.3389/fbioe.2018.00098 Text en Copyright © 2018 Piotto, Julier and Martino. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Piotto, Celeste Julier, Ziad Martino, Mikaël M. Immune Regulation of Tissue Repair and Regeneration via miRNAs—New Therapeutic Target |
title | Immune Regulation of Tissue Repair and Regeneration via miRNAs—New Therapeutic Target |
title_full | Immune Regulation of Tissue Repair and Regeneration via miRNAs—New Therapeutic Target |
title_fullStr | Immune Regulation of Tissue Repair and Regeneration via miRNAs—New Therapeutic Target |
title_full_unstemmed | Immune Regulation of Tissue Repair and Regeneration via miRNAs—New Therapeutic Target |
title_short | Immune Regulation of Tissue Repair and Regeneration via miRNAs—New Therapeutic Target |
title_sort | immune regulation of tissue repair and regeneration via mirnas—new therapeutic target |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053520/ https://www.ncbi.nlm.nih.gov/pubmed/30057898 http://dx.doi.org/10.3389/fbioe.2018.00098 |
work_keys_str_mv | AT piottoceleste immuneregulationoftissuerepairandregenerationviamirnasnewtherapeutictarget AT julierziad immuneregulationoftissuerepairandregenerationviamirnasnewtherapeutictarget AT martinomikaelm immuneregulationoftissuerepairandregenerationviamirnasnewtherapeutictarget |