Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here, we have investigated conditional deletion of Scap or of Insig1 and Insig2 (Scap inhibits intracellular biosynthesis and Insig proteins activate intracellular bio...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsushima, Hidetoshi, Tang, Yuning J., Puviindran, Vijitha, Hsu, Shu-Hsuan Claire, Nadesan, Puviindran, Yu, Chunying, Zhang, Hongyuan, Mirando, Anthony J., Hilton, Matthew J., Alman, Benjamin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053657/
https://www.ncbi.nlm.nih.gov/pubmed/29899135
http://dx.doi.org/10.1242/dev.162396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053657/
https://www.ncbi.nlm.nih.gov/pubmed/29899135
http://dx.doi.org/10.1242/dev.162396

Ejemplares similares