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Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study
Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arteria...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053697/ https://www.ncbi.nlm.nih.gov/pubmed/30079239 http://dx.doi.org/10.12688/f1000research.14198.2 |
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author | Dinas, Petros C. Nintou, Eleni Psychou, Dimitra Granzotto, Marnie Rossato, Marco Vettor, Roberto Jamurtas, Athanasios Z. Koutedakis, Yiannis Metsios, George S. Flouris, Andreas D. |
author_facet | Dinas, Petros C. Nintou, Eleni Psychou, Dimitra Granzotto, Marnie Rossato, Marco Vettor, Roberto Jamurtas, Athanasios Z. Koutedakis, Yiannis Metsios, George S. Flouris, Andreas D. |
author_sort | Dinas, Petros C. |
collection | PubMed |
description | Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.06±7.36, BMI: 27.60±4.63 (kg/m (2))] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R (2)=0.16, p=0.03) and BMI (r=-0.45, R (2)=0.20, p=0.01). Cohen’s f (2) effect size analyses showed a small effect size between NPRA mRNA and BMI ( f (2)=0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen’s d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m (2)) and either normal weight (BMI=19-25 kg/m (2); d=0.94) or overweight (BMI=25-30 kg/m (2); d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation. |
format | Online Article Text |
id | pubmed-6053697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-60536972018-08-02 Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study Dinas, Petros C. Nintou, Eleni Psychou, Dimitra Granzotto, Marnie Rossato, Marco Vettor, Roberto Jamurtas, Athanasios Z. Koutedakis, Yiannis Metsios, George S. Flouris, Andreas D. F1000Res Research Article Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.06±7.36, BMI: 27.60±4.63 (kg/m (2))] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R (2)=0.16, p=0.03) and BMI (r=-0.45, R (2)=0.20, p=0.01). Cohen’s f (2) effect size analyses showed a small effect size between NPRA mRNA and BMI ( f (2)=0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen’s d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m (2)) and either normal weight (BMI=19-25 kg/m (2); d=0.94) or overweight (BMI=25-30 kg/m (2); d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation. F1000 Research Limited 2018-07-18 /pmc/articles/PMC6053697/ /pubmed/30079239 http://dx.doi.org/10.12688/f1000research.14198.2 Text en Copyright: © 2018 Dinas PC et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dinas, Petros C. Nintou, Eleni Psychou, Dimitra Granzotto, Marnie Rossato, Marco Vettor, Roberto Jamurtas, Athanasios Z. Koutedakis, Yiannis Metsios, George S. Flouris, Andreas D. Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study |
title | Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study |
title_full | Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study |
title_fullStr | Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study |
title_full_unstemmed | Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study |
title_short | Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study |
title_sort | association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053697/ https://www.ncbi.nlm.nih.gov/pubmed/30079239 http://dx.doi.org/10.12688/f1000research.14198.2 |
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