De novo design of isopeptide bond-tethered triple-stranded coiled coils with exceptional resistance to unfolding and proteolysis: implication for developing antiviral therapeutics

Isopeptide bond-tethered triple-stranded coiled coils of HIV-1 gp41 N-terminal heptad repeat (NHR) peptides have been designed with de novo auxiliaries to guide site-directed trimerized cross-linking. The presence of isopeptide bridges in the rationally designed trimerization motifs provides extraor...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Lai, Wenqing, Yu, Fei, Zhang, Tianhong, Lu, Lu, Jiang, Xifeng, Zhang, Zhenqing, Xu, Xiaoyu, Bai, Yu, Jiang, Shibo, Liu, Keliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054081/
https://www.ncbi.nlm.nih.gov/pubmed/30090269
http://dx.doi.org/10.1039/c5sc02220g

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