Cargando…

A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies

A systematic review was used to identify randomized controlled trials (RCTs) and observational epidemiologic studies (OBSs) that examined protein intake consistent with either the US RDA (0.8 g/kg or 10–15% of energy) or a higher protein intake (≥20% but <35% of energy or ≥10% higher than a compa...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Elswyk, Mary E, Weatherford, Charli A, McNeill, Shalene H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054213/
https://www.ncbi.nlm.nih.gov/pubmed/30032227
http://dx.doi.org/10.1093/advances/nmy026
_version_ 1783340972057296896
author Van Elswyk, Mary E
Weatherford, Charli A
McNeill, Shalene H
author_facet Van Elswyk, Mary E
Weatherford, Charli A
McNeill, Shalene H
author_sort Van Elswyk, Mary E
collection PubMed
description A systematic review was used to identify randomized controlled trials (RCTs) and observational epidemiologic studies (OBSs) that examined protein intake consistent with either the US RDA (0.8 g/kg or 10–15% of energy) or a higher protein intake (≥20% but <35% of energy or ≥10% higher than a comparison intake) and reported measures of kidney function. Studies (n = 26) of healthy, free-living adults (>18 y old) with or without metabolic disease risk factors were included. Studies of subjects with overt disease, such as chronic kidney, end-stage renal disease, cancer, or organ transplant, were excluded. The most commonly reported variable was glomerular filtration rate (GFR), with 13 RCTs comparing GFRs obtained with normal and higher protein intakes. Most (n = 8), but not all (n = 5), RCTs reported significantly higher GFRs in response to increased protein intake, and all rates were consistent with normal kidney function in healthy adults. The evidence from the current review is limited and inconsistent with regard to the role of protein intake and the risk of kidney stones. Increased protein intake had little or no effect on blood markers of kidney function. Evidence reported here suggests that protein intake above the US RDA has no adverse effect on blood pressure. All included studies were of moderate to high risk of bias and, with the exception of 2 included cohorts, were limited in duration (i.e. <6 mo). Data in the current review are insufficient to determine if increased protein intake from a particular source, i.e., plant or animal, influences kidney health outcomes. These data further indicate that, at least in the short term, higher protein intake within the range of recommended intakes for protein is consistent with normal kidney function in healthy individuals.
format Online
Article
Text
id pubmed-6054213
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-60542132018-07-25 A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies Van Elswyk, Mary E Weatherford, Charli A McNeill, Shalene H Adv Nutr Review A systematic review was used to identify randomized controlled trials (RCTs) and observational epidemiologic studies (OBSs) that examined protein intake consistent with either the US RDA (0.8 g/kg or 10–15% of energy) or a higher protein intake (≥20% but <35% of energy or ≥10% higher than a comparison intake) and reported measures of kidney function. Studies (n = 26) of healthy, free-living adults (>18 y old) with or without metabolic disease risk factors were included. Studies of subjects with overt disease, such as chronic kidney, end-stage renal disease, cancer, or organ transplant, were excluded. The most commonly reported variable was glomerular filtration rate (GFR), with 13 RCTs comparing GFRs obtained with normal and higher protein intakes. Most (n = 8), but not all (n = 5), RCTs reported significantly higher GFRs in response to increased protein intake, and all rates were consistent with normal kidney function in healthy adults. The evidence from the current review is limited and inconsistent with regard to the role of protein intake and the risk of kidney stones. Increased protein intake had little or no effect on blood markers of kidney function. Evidence reported here suggests that protein intake above the US RDA has no adverse effect on blood pressure. All included studies were of moderate to high risk of bias and, with the exception of 2 included cohorts, were limited in duration (i.e. <6 mo). Data in the current review are insufficient to determine if increased protein intake from a particular source, i.e., plant or animal, influences kidney health outcomes. These data further indicate that, at least in the short term, higher protein intake within the range of recommended intakes for protein is consistent with normal kidney function in healthy individuals. Oxford University Press 2018-07-19 2018-07 /pmc/articles/PMC6054213/ /pubmed/30032227 http://dx.doi.org/10.1093/advances/nmy026 Text en © 2018 American Society for Nutrition. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review
Van Elswyk, Mary E
Weatherford, Charli A
McNeill, Shalene H
A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies
title A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies
title_full A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies
title_fullStr A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies
title_full_unstemmed A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies
title_short A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies
title_sort systematic review of renal health in healthy individuals associated with protein intake above the us recommended daily allowance in randomized controlled trials and observational studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054213/
https://www.ncbi.nlm.nih.gov/pubmed/30032227
http://dx.doi.org/10.1093/advances/nmy026
work_keys_str_mv AT vanelswykmarye asystematicreviewofrenalhealthinhealthyindividualsassociatedwithproteinintakeabovetheusrecommendeddailyallowanceinrandomizedcontrolledtrialsandobservationalstudies
AT weatherfordcharlia asystematicreviewofrenalhealthinhealthyindividualsassociatedwithproteinintakeabovetheusrecommendeddailyallowanceinrandomizedcontrolledtrialsandobservationalstudies
AT mcneillshaleneh asystematicreviewofrenalhealthinhealthyindividualsassociatedwithproteinintakeabovetheusrecommendeddailyallowanceinrandomizedcontrolledtrialsandobservationalstudies
AT vanelswykmarye systematicreviewofrenalhealthinhealthyindividualsassociatedwithproteinintakeabovetheusrecommendeddailyallowanceinrandomizedcontrolledtrialsandobservationalstudies
AT weatherfordcharlia systematicreviewofrenalhealthinhealthyindividualsassociatedwithproteinintakeabovetheusrecommendeddailyallowanceinrandomizedcontrolledtrialsandobservationalstudies
AT mcneillshaleneh systematicreviewofrenalhealthinhealthyindividualsassociatedwithproteinintakeabovetheusrecommendeddailyallowanceinrandomizedcontrolledtrialsandobservationalstudies