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Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

AIMS: GTP cyclohydrolase I catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS). Both eNOS and iNOS have been implicated in the progression of atherosclerosis, with opposing effects in eNOS and iNOS knock...

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Detalles Bibliográficos
Autores principales:	Douglas, Gillian, Hale, Ashley B, Patel, Jyoti, Chuaiphichai, Surawee, Al Haj Zen, Ayman, Rashbrook, Victoria S, Trelfa, Lucy, Crabtree, Mark J, McNeill, Eileen, Channon, Keith M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054219/ https://www.ncbi.nlm.nih.gov/pubmed/29596571 http://dx.doi.org/10.1093/cvr/cvy078

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