Cargando…
Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy
Cardiac activity can induce dose–volume evaluation errors for cardiac structures. The purpose of this study was to quantify the variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium (LVM) throughout the cardiac circle. The heart, pericardium and LVM of 22 pat...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054222/ https://www.ncbi.nlm.nih.gov/pubmed/29659977 http://dx.doi.org/10.1093/jrr/rry026 |
_version_ | 1783340973748649984 |
---|---|
author | Tong, Ying Yin, Yong Cheng, Pinjing Lu, Jie Liu, Tonghai Chen, Jinhu Gong, Guanzhong |
author_facet | Tong, Ying Yin, Yong Cheng, Pinjing Lu, Jie Liu, Tonghai Chen, Jinhu Gong, Guanzhong |
author_sort | Tong, Ying |
collection | PubMed |
description | Cardiac activity can induce dose–volume evaluation errors for cardiac structures. The purpose of this study was to quantify the variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium (LVM) throughout the cardiac circle. The heart, pericardium and LVM of 22 patients were contoured on 20 phases of electrocardiography-gated 4D computed tomography (4DCT) images acquired during breath-hold. Radiotherapy plans were designed on 0% phase of the 4DCT images, and the dose distributions of the plans were imported into MIM Maestro and deformed to each phase to generate distributions for all phases. Variations in dose–volume parameters for the heart, pericardium and LVM were compared among different phases. The rates of variation in D(mean) for the heart and pericardium were 3.33 ± 1.04% and 2.66 ± 1.15%, respectively. The mean values of the maximum difference in V(5), V(10), V(20), V(30) and V(40) were all <2% for the heart and pericardium and were not statistically significant (P > 0.05). The rate of variation in D(mean) for the LVM reached 87.05 ± 38.34%, and the maximum differences in V(5), V(10), V(20), V(30) and V(40) were 13.76 ± 4.46%, 13.64 ± 4.33%, 12.84 ± 4.55%, 11.62 ± 4.85% and 3.63 ± 2.56%, respectively; all differences were statistically significant (P < 0.05). Variations in dose–volume parameters were more significant in the LVM than in the heart and pericardium (P < 0.05). The dose–volume parameters for the LVM were significantly influenced by cardiac activity, whereas those for the heart and pericardium were not; therefore, individual dosimetric evaluation and limitation must be performed for the LVM. |
format | Online Article Text |
id | pubmed-6054222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60542222018-07-25 Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy Tong, Ying Yin, Yong Cheng, Pinjing Lu, Jie Liu, Tonghai Chen, Jinhu Gong, Guanzhong J Radiat Res Regular Paper Cardiac activity can induce dose–volume evaluation errors for cardiac structures. The purpose of this study was to quantify the variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium (LVM) throughout the cardiac circle. The heart, pericardium and LVM of 22 patients were contoured on 20 phases of electrocardiography-gated 4D computed tomography (4DCT) images acquired during breath-hold. Radiotherapy plans were designed on 0% phase of the 4DCT images, and the dose distributions of the plans were imported into MIM Maestro and deformed to each phase to generate distributions for all phases. Variations in dose–volume parameters for the heart, pericardium and LVM were compared among different phases. The rates of variation in D(mean) for the heart and pericardium were 3.33 ± 1.04% and 2.66 ± 1.15%, respectively. The mean values of the maximum difference in V(5), V(10), V(20), V(30) and V(40) were all <2% for the heart and pericardium and were not statistically significant (P > 0.05). The rate of variation in D(mean) for the LVM reached 87.05 ± 38.34%, and the maximum differences in V(5), V(10), V(20), V(30) and V(40) were 13.76 ± 4.46%, 13.64 ± 4.33%, 12.84 ± 4.55%, 11.62 ± 4.85% and 3.63 ± 2.56%, respectively; all differences were statistically significant (P < 0.05). Variations in dose–volume parameters were more significant in the LVM than in the heart and pericardium (P < 0.05). The dose–volume parameters for the LVM were significantly influenced by cardiac activity, whereas those for the heart and pericardium were not; therefore, individual dosimetric evaluation and limitation must be performed for the LVM. Oxford University Press 2018-07 2018-04-05 /pmc/articles/PMC6054222/ /pubmed/29659977 http://dx.doi.org/10.1093/jrr/rry026 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Regular Paper Tong, Ying Yin, Yong Cheng, Pinjing Lu, Jie Liu, Tonghai Chen, Jinhu Gong, Guanzhong Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy |
title | Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy |
title_full | Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy |
title_fullStr | Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy |
title_full_unstemmed | Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy |
title_short | Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy |
title_sort | quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy |
topic | Regular Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054222/ https://www.ncbi.nlm.nih.gov/pubmed/29659977 http://dx.doi.org/10.1093/jrr/rry026 |
work_keys_str_mv | AT tongying quantificationofvariationindosevolumeparametersfortheheartpericardiumandleftventricularmyocardiumduringthoracictumorradiotherapy AT yinyong quantificationofvariationindosevolumeparametersfortheheartpericardiumandleftventricularmyocardiumduringthoracictumorradiotherapy AT chengpinjing quantificationofvariationindosevolumeparametersfortheheartpericardiumandleftventricularmyocardiumduringthoracictumorradiotherapy AT lujie quantificationofvariationindosevolumeparametersfortheheartpericardiumandleftventricularmyocardiumduringthoracictumorradiotherapy AT liutonghai quantificationofvariationindosevolumeparametersfortheheartpericardiumandleftventricularmyocardiumduringthoracictumorradiotherapy AT chenjinhu quantificationofvariationindosevolumeparametersfortheheartpericardiumandleftventricularmyocardiumduringthoracictumorradiotherapy AT gongguanzhong quantificationofvariationindosevolumeparametersfortheheartpericardiumandleftventricularmyocardiumduringthoracictumorradiotherapy |