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Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy

Cardiac activity can induce dose–volume evaluation errors for cardiac structures. The purpose of this study was to quantify the variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium (LVM) throughout the cardiac circle. The heart, pericardium and LVM of 22 pat...

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Autores principales: Tong, Ying, Yin, Yong, Cheng, Pinjing, Lu, Jie, Liu, Tonghai, Chen, Jinhu, Gong, Guanzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054222/
https://www.ncbi.nlm.nih.gov/pubmed/29659977
http://dx.doi.org/10.1093/jrr/rry026
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author Tong, Ying
Yin, Yong
Cheng, Pinjing
Lu, Jie
Liu, Tonghai
Chen, Jinhu
Gong, Guanzhong
author_facet Tong, Ying
Yin, Yong
Cheng, Pinjing
Lu, Jie
Liu, Tonghai
Chen, Jinhu
Gong, Guanzhong
author_sort Tong, Ying
collection PubMed
description Cardiac activity can induce dose–volume evaluation errors for cardiac structures. The purpose of this study was to quantify the variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium (LVM) throughout the cardiac circle. The heart, pericardium and LVM of 22 patients were contoured on 20 phases of electrocardiography-gated 4D computed tomography (4DCT) images acquired during breath-hold. Radiotherapy plans were designed on 0% phase of the 4DCT images, and the dose distributions of the plans were imported into MIM Maestro and deformed to each phase to generate distributions for all phases. Variations in dose–volume parameters for the heart, pericardium and LVM were compared among different phases. The rates of variation in D(mean) for the heart and pericardium were 3.33 ± 1.04% and 2.66 ± 1.15%, respectively. The mean values of the maximum difference in V(5), V(10), V(20), V(30) and V(40) were all <2% for the heart and pericardium and were not statistically significant (P > 0.05). The rate of variation in D(mean) for the LVM reached 87.05 ± 38.34%, and the maximum differences in V(5), V(10), V(20), V(30) and V(40) were 13.76 ± 4.46%, 13.64 ± 4.33%, 12.84 ± 4.55%, 11.62 ± 4.85% and 3.63 ± 2.56%, respectively; all differences were statistically significant (P < 0.05). Variations in dose–volume parameters were more significant in the LVM than in the heart and pericardium (P < 0.05). The dose–volume parameters for the LVM were significantly influenced by cardiac activity, whereas those for the heart and pericardium were not; therefore, individual dosimetric evaluation and limitation must be performed for the LVM.
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spelling pubmed-60542222018-07-25 Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy Tong, Ying Yin, Yong Cheng, Pinjing Lu, Jie Liu, Tonghai Chen, Jinhu Gong, Guanzhong J Radiat Res Regular Paper Cardiac activity can induce dose–volume evaluation errors for cardiac structures. The purpose of this study was to quantify the variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium (LVM) throughout the cardiac circle. The heart, pericardium and LVM of 22 patients were contoured on 20 phases of electrocardiography-gated 4D computed tomography (4DCT) images acquired during breath-hold. Radiotherapy plans were designed on 0% phase of the 4DCT images, and the dose distributions of the plans were imported into MIM Maestro and deformed to each phase to generate distributions for all phases. Variations in dose–volume parameters for the heart, pericardium and LVM were compared among different phases. The rates of variation in D(mean) for the heart and pericardium were 3.33 ± 1.04% and 2.66 ± 1.15%, respectively. The mean values of the maximum difference in V(5), V(10), V(20), V(30) and V(40) were all <2% for the heart and pericardium and were not statistically significant (P > 0.05). The rate of variation in D(mean) for the LVM reached 87.05 ± 38.34%, and the maximum differences in V(5), V(10), V(20), V(30) and V(40) were 13.76 ± 4.46%, 13.64 ± 4.33%, 12.84 ± 4.55%, 11.62 ± 4.85% and 3.63 ± 2.56%, respectively; all differences were statistically significant (P < 0.05). Variations in dose–volume parameters were more significant in the LVM than in the heart and pericardium (P < 0.05). The dose–volume parameters for the LVM were significantly influenced by cardiac activity, whereas those for the heart and pericardium were not; therefore, individual dosimetric evaluation and limitation must be performed for the LVM. Oxford University Press 2018-07 2018-04-05 /pmc/articles/PMC6054222/ /pubmed/29659977 http://dx.doi.org/10.1093/jrr/rry026 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Regular Paper
Tong, Ying
Yin, Yong
Cheng, Pinjing
Lu, Jie
Liu, Tonghai
Chen, Jinhu
Gong, Guanzhong
Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy
title Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy
title_full Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy
title_fullStr Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy
title_full_unstemmed Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy
title_short Quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy
title_sort quantification of variation in dose–volume parameters for the heart, pericardium and left ventricular myocardium during thoracic tumor radiotherapy
topic Regular Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054222/
https://www.ncbi.nlm.nih.gov/pubmed/29659977
http://dx.doi.org/10.1093/jrr/rry026
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