Cargando…

Myelopathy from Intradural Extramedullary Metastasis as an Initial Presentation of Metastatic Melanoma

The incidence of metastatic melanoma (MM) has been steadily rising, and it is the third most common metastatic lesion to the central nervous system (CNS). Spinal intradural extramedullary (IDEM) MM is rare, and it is associated with coexisting or antecedent brain metastasis. Metastatic disease to th...

Descripción completa

Detalles Bibliográficos
Autores principales: Stein, Alan A, Weinstein, Gila R, Niezgoda, Colin, Chowdhary, Sajeel, Vrionis, Frank, Houten, John K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054369/
https://www.ncbi.nlm.nih.gov/pubmed/30042919
http://dx.doi.org/10.7759/cureus.2668
_version_ 1783340991078465536
author Stein, Alan A
Weinstein, Gila R
Niezgoda, Colin
Chowdhary, Sajeel
Vrionis, Frank
Houten, John K
author_facet Stein, Alan A
Weinstein, Gila R
Niezgoda, Colin
Chowdhary, Sajeel
Vrionis, Frank
Houten, John K
author_sort Stein, Alan A
collection PubMed
description The incidence of metastatic melanoma (MM) has been steadily rising, and it is the third most common metastatic lesion to the central nervous system (CNS). Spinal intradural extramedullary (IDEM) MM is rare, and it is associated with coexisting or antecedent brain metastasis. Metastatic disease to the CNS is a complication of advanced disease, and it generally occurs months to years after initial diagnosis and treatment. We describe the first case of an initial presentation of MM, presenting as cervical myelopathy secondary to spinal cord compression from IDEM spinal metastasis. Further work-up revealed additional lesions in the temporal lobe and cauda equina region as well as a scalp lesion that was presumed to be the primary site. MM should be considered in the differential of myelopathy secondary to a spinal intradural mass, particularly in those with a history of or risk factors for melanoma.
format Online
Article
Text
id pubmed-6054369
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-60543692018-07-24 Myelopathy from Intradural Extramedullary Metastasis as an Initial Presentation of Metastatic Melanoma Stein, Alan A Weinstein, Gila R Niezgoda, Colin Chowdhary, Sajeel Vrionis, Frank Houten, John K Cureus Neurology The incidence of metastatic melanoma (MM) has been steadily rising, and it is the third most common metastatic lesion to the central nervous system (CNS). Spinal intradural extramedullary (IDEM) MM is rare, and it is associated with coexisting or antecedent brain metastasis. Metastatic disease to the CNS is a complication of advanced disease, and it generally occurs months to years after initial diagnosis and treatment. We describe the first case of an initial presentation of MM, presenting as cervical myelopathy secondary to spinal cord compression from IDEM spinal metastasis. Further work-up revealed additional lesions in the temporal lobe and cauda equina region as well as a scalp lesion that was presumed to be the primary site. MM should be considered in the differential of myelopathy secondary to a spinal intradural mass, particularly in those with a history of or risk factors for melanoma. Cureus 2018-05-22 /pmc/articles/PMC6054369/ /pubmed/30042919 http://dx.doi.org/10.7759/cureus.2668 Text en Copyright © 2018, Stein et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Stein, Alan A
Weinstein, Gila R
Niezgoda, Colin
Chowdhary, Sajeel
Vrionis, Frank
Houten, John K
Myelopathy from Intradural Extramedullary Metastasis as an Initial Presentation of Metastatic Melanoma
title Myelopathy from Intradural Extramedullary Metastasis as an Initial Presentation of Metastatic Melanoma
title_full Myelopathy from Intradural Extramedullary Metastasis as an Initial Presentation of Metastatic Melanoma
title_fullStr Myelopathy from Intradural Extramedullary Metastasis as an Initial Presentation of Metastatic Melanoma
title_full_unstemmed Myelopathy from Intradural Extramedullary Metastasis as an Initial Presentation of Metastatic Melanoma
title_short Myelopathy from Intradural Extramedullary Metastasis as an Initial Presentation of Metastatic Melanoma
title_sort myelopathy from intradural extramedullary metastasis as an initial presentation of metastatic melanoma
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054369/
https://www.ncbi.nlm.nih.gov/pubmed/30042919
http://dx.doi.org/10.7759/cureus.2668
work_keys_str_mv AT steinalana myelopathyfromintraduralextramedullarymetastasisasaninitialpresentationofmetastaticmelanoma
AT weinsteingilar myelopathyfromintraduralextramedullarymetastasisasaninitialpresentationofmetastaticmelanoma
AT niezgodacolin myelopathyfromintraduralextramedullarymetastasisasaninitialpresentationofmetastaticmelanoma
AT chowdharysajeel myelopathyfromintraduralextramedullarymetastasisasaninitialpresentationofmetastaticmelanoma
AT vrionisfrank myelopathyfromintraduralextramedullarymetastasisasaninitialpresentationofmetastaticmelanoma
AT houtenjohnk myelopathyfromintraduralextramedullarymetastasisasaninitialpresentationofmetastaticmelanoma