Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation

Patients with both major forms of diabetes would benefit from therapies that increase β-cell mass. Glucose, a natural mitogen, drives adaptive expansion of β-cell mass by promoting β-cell proliferation. We previously demonstrated that a carbohydrate response element–binding protein (ChREBPα) is requ...

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Detalles Bibliográficos
Autores principales: Kumar, Anil, Katz, Liora S., Schulz, Anna M., Kim, Misung, Honig, Lee B., Li, Lucy, Davenport, Bennett, Homann, Dirk, Garcia-Ocaña, Adolfo, Herman, Mark A., Haynes, Cole M., Chipuk, Jerry E., Scott, Donald K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2018
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054434/
https://www.ncbi.nlm.nih.gov/pubmed/29764859
http://dx.doi.org/10.2337/db17-0943

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