Variability of Directly Measured First-Pass Hepatic Insulin Extraction and Its Association With Insulin Sensitivity and Plasma Insulin

Although the β-cells secrete insulin, the liver, with its first-pass insulin extraction (FPE), regulates the amount of insulin allowed into circulation for action on target tissues. The metabolic clearance rate of insulin, of which FPE is the dominant component, is a major determinant of insulin sen...

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Detalles Bibliográficos
Autores principales: Asare-Bediako, Isaac, Paszkiewicz, Rebecca L., Kim, Stella P., Woolcott, Orison O., Kolka, Cathryn M., Burch, Miguel A., Kabir, Morvarid, Bergman, Richard N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2018
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054441/
https://www.ncbi.nlm.nih.gov/pubmed/29752425
http://dx.doi.org/10.2337/db17-1520

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