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Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study
Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A(1c) (HbA(1c)) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide association studies of fructosamine and glycated albumin among 2,1...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054442/ https://www.ncbi.nlm.nih.gov/pubmed/29844224 http://dx.doi.org/10.2337/db17-1362 |
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author | Loomis, Stephanie J. Li, Man Maruthur, Nisa M. Baldridge, Abigail S. North, Kari E. Mei, Hao Morrison, Alanna Carson, April P. Pankow, James S. Boerwinkle, Eric Scharpf, Robert Rasmussen-Torvik, Laura J. Coresh, Josef Duggal, Priya Köttgen, Anna Selvin, Elizabeth |
author_facet | Loomis, Stephanie J. Li, Man Maruthur, Nisa M. Baldridge, Abigail S. North, Kari E. Mei, Hao Morrison, Alanna Carson, April P. Pankow, James S. Boerwinkle, Eric Scharpf, Robert Rasmussen-Torvik, Laura J. Coresh, Josef Duggal, Priya Köttgen, Anna Selvin, Elizabeth |
author_sort | Loomis, Stephanie J. |
collection | PubMed |
description | Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A(1c) (HbA(1c)) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide association studies of fructosamine and glycated albumin among 2,104 black and 7,647 white participants without diabetes in the Atherosclerosis Risk in Communities (ARIC) Study and replicated findings in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Among whites, rs34459162, a novel missense single nucleotide polymorphism (SNP) in RCN3, was associated with fructosamine (P = 5.3 × 10(−9)) and rs1260236, a known diabetes-related missense mutation in GCKR, was associated with percent glycated albumin (P = 5.9 × 10(−9)) and replicated in CARDIA. We also found two novel associations among blacks: an intergenic SNP, rs2438321, associated with fructosamine (P = 6.2 × 10(−9)), and an intronic variant in PRKCA, rs59443763, associated with percent glycated albumin (P = 4.1 × 10(−9)), but these results did not replicate. Few established fasting glucose or HbA(1c) SNPs were also associated with fructosamine or glycated albumin. Overall, we found genetic variants associated with the glycemic information captured by fructosamine and glycated albumin as well as with their nonglycemic component. This highlights the importance of examining the genetics of hyperglycemia biomarkers to understand the information they capture, including potential glucose-independent factors. |
format | Online Article Text |
id | pubmed-6054442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-60544422019-08-01 Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study Loomis, Stephanie J. Li, Man Maruthur, Nisa M. Baldridge, Abigail S. North, Kari E. Mei, Hao Morrison, Alanna Carson, April P. Pankow, James S. Boerwinkle, Eric Scharpf, Robert Rasmussen-Torvik, Laura J. Coresh, Josef Duggal, Priya Köttgen, Anna Selvin, Elizabeth Diabetes Genetics/Genomes/Proteomics/Metabolomics Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A(1c) (HbA(1c)) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide association studies of fructosamine and glycated albumin among 2,104 black and 7,647 white participants without diabetes in the Atherosclerosis Risk in Communities (ARIC) Study and replicated findings in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Among whites, rs34459162, a novel missense single nucleotide polymorphism (SNP) in RCN3, was associated with fructosamine (P = 5.3 × 10(−9)) and rs1260236, a known diabetes-related missense mutation in GCKR, was associated with percent glycated albumin (P = 5.9 × 10(−9)) and replicated in CARDIA. We also found two novel associations among blacks: an intergenic SNP, rs2438321, associated with fructosamine (P = 6.2 × 10(−9)), and an intronic variant in PRKCA, rs59443763, associated with percent glycated albumin (P = 4.1 × 10(−9)), but these results did not replicate. Few established fasting glucose or HbA(1c) SNPs were also associated with fructosamine or glycated albumin. Overall, we found genetic variants associated with the glycemic information captured by fructosamine and glycated albumin as well as with their nonglycemic component. This highlights the importance of examining the genetics of hyperglycemia biomarkers to understand the information they capture, including potential glucose-independent factors. American Diabetes Association 2018-08 2018-05-29 /pmc/articles/PMC6054442/ /pubmed/29844224 http://dx.doi.org/10.2337/db17-1362 Text en © 2018 by the American Diabetes Association. http://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license. |
spellingShingle | Genetics/Genomes/Proteomics/Metabolomics Loomis, Stephanie J. Li, Man Maruthur, Nisa M. Baldridge, Abigail S. North, Kari E. Mei, Hao Morrison, Alanna Carson, April P. Pankow, James S. Boerwinkle, Eric Scharpf, Robert Rasmussen-Torvik, Laura J. Coresh, Josef Duggal, Priya Köttgen, Anna Selvin, Elizabeth Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study |
title | Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study |
title_full | Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study |
title_fullStr | Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study |
title_full_unstemmed | Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study |
title_short | Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study |
title_sort | genome-wide association study of serum fructosamine and glycated albumin in adults without diagnosed diabetes: results from the atherosclerosis risk in communities study |
topic | Genetics/Genomes/Proteomics/Metabolomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054442/ https://www.ncbi.nlm.nih.gov/pubmed/29844224 http://dx.doi.org/10.2337/db17-1362 |
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