Cargando…

Mechano-redox control of integrin de-adhesion

How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples ligand binding and force to trigger a chemical event which controls the adhesive properties of the receptor. Our studies of the secreted platele...

Descripción completa

Detalles Bibliográficos
Autores principales:	Passam, Freda, Chiu, Joyce, Ju, Lining, Pijning, Aster, Jahan, Zeenat, Mor-Cohen, Ronit, Yeheskel, Adva, Kolšek, Katra, Thärichen, Lena, Aponte-Santamaría, Camilo, Gräter, Frauke, Hogg, Philip J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054529/ https://www.ncbi.nlm.nih.gov/pubmed/29932420 http://dx.doi.org/10.7554/eLife.34843

Ejemplares similares

Accessibility explains preferred thiol-disulfide isomerization in a protein domain
por: Kolšek, Katra, et al.
Publicado: (2017)

The mechano-sensing role of the unique SH3 insertion in plakin domains revealed by Molecular Dynamics simulations
por: Daday, Csaba, et al.
Publicado: (2017)

An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function
por: Pijning, Aster E., et al.
Publicado: (2021)

Identification of allosteric disulfides from labile bonds in X-ray structures
por: Pijning, Aster E., et al.
Publicado: (2018)

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo
por: Röper, Jens-Christian, et al.
Publicado: (2018)

Autoregulation of von Willebrand factor function by a disulfide bond switch
por: Butera, Diego, et al.
Publicado: (2018)

Inositol hexakisphosphate increases the size of platelet aggregates
por: Brehm, Maria A., et al.
Publicado: (2019)

Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress
por: Imber, Marcel, et al.
Publicado: (2018)

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis
por: Gupta, Ritu, et al.
Publicado: (2019)

Mechanism of Focal Adhesion Kinase Mechanosensing
por: Zhou, Jing, et al.
Publicado: (2015)

Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds
por: Entova, Sonya, et al.
Publicado: (2018)

ICE1 promotes the link between splicing and nonsense-mediated mRNA decay
por: Baird, Thomas D, et al.
Publicado: (2018)

Straight Channel Microfluidic Chips for the Study of Platelet Adhesion under Flow
por: Dupuy, Alexander, et al.
Publicado: (2019)

Retraction: Pyrophosphate modulates plant stress responses via SUMOylation
por: Patir Nebioglu, M Görkem, et al.
Publicado: (2019)

Pyrophosphate modulates plant stress responses via SUMOylation
por: Patir-Nebioglu, M Görkem, et al.
Publicado: (2019)

Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation
por: Case, Lindsay B, et al.
Publicado: (2022)

The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice
por: Clarke, Benjamin A, et al.
Publicado: (2019)

Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state
por: Li, Jing, et al.
Publicado: (2021)

Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
por: Kastenhuber, Edward R, et al.
Publicado: (2022)

Mechano-covalent protection of coagulation factor VIII by von Willebrand factor
por: Butera, Diego, et al.
Publicado: (2022)

Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine
por: Chen, Yunfeng, et al.
Publicado: (2019)

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
por: Zhang, Li, et al.
Publicado: (2015)

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
por: Overman, Jeroen, et al.
Publicado: (2017)

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation
por: Mourão, André, et al.
Publicado: (2016)

The gating cycle of a K(+) channel at atomic resolution
por: Cuello, Luis G, et al.
Publicado: (2017)

CK1/Doubletime activity delays transcription activation in the circadian clock
por: Top, Deniz, et al.
Publicado: (2018)

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
por: Kopp, Megan C, et al.
Publicado: (2018)

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast
por: Martin-Marcos, Pilar, et al.
Publicado: (2017)

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure
por: Gao, Jieqiong, et al.
Publicado: (2018)

Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival
por: Tien, Matthew, et al.
Publicado: (2018)

Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping
por: Tian, Siqi, et al.
Publicado: (2018)

Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima
por: Morgunova, Ekaterina, et al.
Publicado: (2018)

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen
por: Shah, Neel H, et al.
Publicado: (2018)

Transitioning to DNA genomes in an RNA world
por: Cojocaru, Razvan, et al.
Publicado: (2017)

A reverse transcriptase ribozyme
por: Samanta, Biswajit, et al.
Publicado: (2017)

AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation
por: Preissler, Steffen, et al.
Publicado: (2017)

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID
por: Gupta, Kapil, et al.
Publicado: (2017)

Structural insight into TPX2-stimulated microtubule assembly
por: Zhang, Rui, et al.
Publicado: (2017)

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
por: Kumar, Atul, et al.
Publicado: (2017)

Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
por: Kühl, Inge, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0qgma4qg615d286gqdta41j7bh