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Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation
A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain’s underlying computations. We investigate how the nematode Caenorhabditis elegans responds to time-varying mechanosensory signals using a h...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054533/ https://www.ncbi.nlm.nih.gov/pubmed/29943731 http://dx.doi.org/10.7554/eLife.36419 |
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author | Liu, Mochi Sharma, Anuj K Shaevitz, Joshua W Leifer, Andrew M |
author_facet | Liu, Mochi Sharma, Anuj K Shaevitz, Joshua W Leifer, Andrew M |
author_sort | Liu, Mochi |
collection | PubMed |
description | A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain’s underlying computations. We investigate how the nematode Caenorhabditis elegans responds to time-varying mechanosensory signals using a high-throughput optogenetic assay and automated behavior quantification. We find that the behavioral response is tuned to temporal properties of mechanosensory signals, such as their integral and derivative, that extend over many seconds. Mechanosensory signals, even in the same neurons, can be tailored to elicit different behavioral responses. Moreover, we find that the animal’s response also depends on its behavioral context. Most dramatically, the animal ignores all tested mechanosensory stimuli during turns. Finally, we present a linear-nonlinear model that predicts the animal’s behavioral response to stimulus. |
format | Online Article Text |
id | pubmed-6054533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60545332018-07-23 Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation Liu, Mochi Sharma, Anuj K Shaevitz, Joshua W Leifer, Andrew M eLife Neuroscience A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain’s underlying computations. We investigate how the nematode Caenorhabditis elegans responds to time-varying mechanosensory signals using a high-throughput optogenetic assay and automated behavior quantification. We find that the behavioral response is tuned to temporal properties of mechanosensory signals, such as their integral and derivative, that extend over many seconds. Mechanosensory signals, even in the same neurons, can be tailored to elicit different behavioral responses. Moreover, we find that the animal’s response also depends on its behavioral context. Most dramatically, the animal ignores all tested mechanosensory stimuli during turns. Finally, we present a linear-nonlinear model that predicts the animal’s behavioral response to stimulus. eLife Sciences Publications, Ltd 2018-06-26 /pmc/articles/PMC6054533/ /pubmed/29943731 http://dx.doi.org/10.7554/eLife.36419 Text en © 2018, Liu et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Liu, Mochi Sharma, Anuj K Shaevitz, Joshua W Leifer, Andrew M Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation |
title | Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation |
title_full | Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation |
title_fullStr | Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation |
title_full_unstemmed | Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation |
title_short | Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation |
title_sort | temporal processing and context dependency in caenorhabditis elegans response to mechanosensation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054533/ https://www.ncbi.nlm.nih.gov/pubmed/29943731 http://dx.doi.org/10.7554/eLife.36419 |
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