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Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation

A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain’s underlying computations. We investigate how the nematode Caenorhabditis elegans responds to time-varying mechanosensory signals using a h...

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Autores principales: Liu, Mochi, Sharma, Anuj K, Shaevitz, Joshua W, Leifer, Andrew M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054533/
https://www.ncbi.nlm.nih.gov/pubmed/29943731
http://dx.doi.org/10.7554/eLife.36419
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author Liu, Mochi
Sharma, Anuj K
Shaevitz, Joshua W
Leifer, Andrew M
author_facet Liu, Mochi
Sharma, Anuj K
Shaevitz, Joshua W
Leifer, Andrew M
author_sort Liu, Mochi
collection PubMed
description A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain’s underlying computations. We investigate how the nematode Caenorhabditis elegans responds to time-varying mechanosensory signals using a high-throughput optogenetic assay and automated behavior quantification. We find that the behavioral response is tuned to temporal properties of mechanosensory signals, such as their integral and derivative, that extend over many seconds. Mechanosensory signals, even in the same neurons, can be tailored to elicit different behavioral responses. Moreover, we find that the animal’s response also depends on its behavioral context. Most dramatically, the animal ignores all tested mechanosensory stimuli during turns. Finally, we present a linear-nonlinear model that predicts the animal’s behavioral response to stimulus.
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spelling pubmed-60545332018-07-23 Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation Liu, Mochi Sharma, Anuj K Shaevitz, Joshua W Leifer, Andrew M eLife Neuroscience A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain’s underlying computations. We investigate how the nematode Caenorhabditis elegans responds to time-varying mechanosensory signals using a high-throughput optogenetic assay and automated behavior quantification. We find that the behavioral response is tuned to temporal properties of mechanosensory signals, such as their integral and derivative, that extend over many seconds. Mechanosensory signals, even in the same neurons, can be tailored to elicit different behavioral responses. Moreover, we find that the animal’s response also depends on its behavioral context. Most dramatically, the animal ignores all tested mechanosensory stimuli during turns. Finally, we present a linear-nonlinear model that predicts the animal’s behavioral response to stimulus. eLife Sciences Publications, Ltd 2018-06-26 /pmc/articles/PMC6054533/ /pubmed/29943731 http://dx.doi.org/10.7554/eLife.36419 Text en © 2018, Liu et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Liu, Mochi
Sharma, Anuj K
Shaevitz, Joshua W
Leifer, Andrew M
Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation
title Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation
title_full Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation
title_fullStr Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation
title_full_unstemmed Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation
title_short Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation
title_sort temporal processing and context dependency in caenorhabditis elegans response to mechanosensation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054533/
https://www.ncbi.nlm.nih.gov/pubmed/29943731
http://dx.doi.org/10.7554/eLife.36419
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