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The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations

It is well-established that baroreflex sensitivity is essential for blood pressure control, and also plays a key role in the modulation of disease-induced metabolic alterations. In order to investigate the role of the baroreflex in the cardiometabolic and inflammatory derangements promoted by fructo...

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Autores principales: dos Santos, Fernando, Moraes-Silva, Ivana C., Moreira, Edson D., Irigoyen, Maria-Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054615/
https://www.ncbi.nlm.nih.gov/pubmed/30030527
http://dx.doi.org/10.1038/s41598-018-29336-3
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author dos Santos, Fernando
Moraes-Silva, Ivana C.
Moreira, Edson D.
Irigoyen, Maria-Claudia
author_facet dos Santos, Fernando
Moraes-Silva, Ivana C.
Moreira, Edson D.
Irigoyen, Maria-Claudia
author_sort dos Santos, Fernando
collection PubMed
description It is well-established that baroreflex sensitivity is essential for blood pressure control, and also plays a key role in the modulation of disease-induced metabolic alterations. In order to investigate the role of the baroreflex in the cardiometabolic and inflammatory derangements promoted by fructose overload, Wistar rats underwent sinoaortic denervation (SAD) or sham surgery and were studied 90 days after receiving tap water (Den and Ctrl) or a 10% fructose solution (Fruc and Den-Fruc). All experimental groups showed marked and similar degree of baroreflex impairment compared to Ctrl. As expected, fructose overload effectively induced metabolic syndrome; however, when it was associated with SAD, several alterations were attenuated. While Fruc rats displayed increased sympathetic modulation and tone and reduced vagal modulation compared to Ctrl animals, Den-Fruc rats showed greater vagal tone and modulation when compared to the Fruc group. Moreover, the Den-Fruc group showed augmented expression of β1 adrenergic receptors and TNF/IL-10 ratio and reduction of β2 in the left ventricle. The increase in vagal function was correlated with improved insulin sensitivity (r(2) = 0.76), and decreased abdominal fat (r(2) = −0.78) and β2 receptors (r(2) = −0.85). Our results showed that: (1) chronic fructose overload induced severe baroreflex impairment, i.e. in a similar magnitude to that observed in SAD rats, which is accompanied by cardiometabolic dysfunctions; (2) the compensatory enhancement in parasympathetic function in SAD rats submitted to fructose intake may point out the possibility of use of approaches that improve vagal function as therapeutic target to attenuate fructose-induced cardiometabolic dysfunctions.
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spelling pubmed-60546152018-07-23 The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations dos Santos, Fernando Moraes-Silva, Ivana C. Moreira, Edson D. Irigoyen, Maria-Claudia Sci Rep Article It is well-established that baroreflex sensitivity is essential for blood pressure control, and also plays a key role in the modulation of disease-induced metabolic alterations. In order to investigate the role of the baroreflex in the cardiometabolic and inflammatory derangements promoted by fructose overload, Wistar rats underwent sinoaortic denervation (SAD) or sham surgery and were studied 90 days after receiving tap water (Den and Ctrl) or a 10% fructose solution (Fruc and Den-Fruc). All experimental groups showed marked and similar degree of baroreflex impairment compared to Ctrl. As expected, fructose overload effectively induced metabolic syndrome; however, when it was associated with SAD, several alterations were attenuated. While Fruc rats displayed increased sympathetic modulation and tone and reduced vagal modulation compared to Ctrl animals, Den-Fruc rats showed greater vagal tone and modulation when compared to the Fruc group. Moreover, the Den-Fruc group showed augmented expression of β1 adrenergic receptors and TNF/IL-10 ratio and reduction of β2 in the left ventricle. The increase in vagal function was correlated with improved insulin sensitivity (r(2) = 0.76), and decreased abdominal fat (r(2) = −0.78) and β2 receptors (r(2) = −0.85). Our results showed that: (1) chronic fructose overload induced severe baroreflex impairment, i.e. in a similar magnitude to that observed in SAD rats, which is accompanied by cardiometabolic dysfunctions; (2) the compensatory enhancement in parasympathetic function in SAD rats submitted to fructose intake may point out the possibility of use of approaches that improve vagal function as therapeutic target to attenuate fructose-induced cardiometabolic dysfunctions. Nature Publishing Group UK 2018-07-20 /pmc/articles/PMC6054615/ /pubmed/30030527 http://dx.doi.org/10.1038/s41598-018-29336-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
dos Santos, Fernando
Moraes-Silva, Ivana C.
Moreira, Edson D.
Irigoyen, Maria-Claudia
The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
title The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
title_full The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
title_fullStr The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
title_full_unstemmed The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
title_short The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
title_sort role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054615/
https://www.ncbi.nlm.nih.gov/pubmed/30030527
http://dx.doi.org/10.1038/s41598-018-29336-3
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