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Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans
The ability of animals to effectively locate and navigate toward food sources is central for survival. Here, using C. elegans nematodes, we reveal the neural mechanism underlying efficient navigation in chemical gradients. This mechanism relies on the activity of two types of chemosensory neurons: o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054637/ https://www.ncbi.nlm.nih.gov/pubmed/30030432 http://dx.doi.org/10.1038/s41467-018-05151-2 |
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author | Itskovits, Eyal Ruach, Rotem Kazakov, Alexander Zaslaver, Alon |
author_facet | Itskovits, Eyal Ruach, Rotem Kazakov, Alexander Zaslaver, Alon |
author_sort | Itskovits, Eyal |
collection | PubMed |
description | The ability of animals to effectively locate and navigate toward food sources is central for survival. Here, using C. elegans nematodes, we reveal the neural mechanism underlying efficient navigation in chemical gradients. This mechanism relies on the activity of two types of chemosensory neurons: one (AWA) coding gradients via stochastic pulsatile dynamics, and the second (AWC(ON)) coding the gradients deterministically in a graded manner. The pulsatile dynamics of the AWA neuron adapts to the magnitude of the gradient derivative, allowing animals to take trajectories better oriented toward the target. The robust response of AWC(ON) to negative derivatives promotes immediate turns, thus alleviating the costs incurred by erroneous turns dictated by the AWA neuron. This mechanism empowers an efficient navigation strategy that outperforms the classical biased-random walk strategy. This general mechanism thus may be applicable to other sensory modalities for efficient gradient-based navigation. |
format | Online Article Text |
id | pubmed-6054637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60546372018-07-26 Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans Itskovits, Eyal Ruach, Rotem Kazakov, Alexander Zaslaver, Alon Nat Commun Article The ability of animals to effectively locate and navigate toward food sources is central for survival. Here, using C. elegans nematodes, we reveal the neural mechanism underlying efficient navigation in chemical gradients. This mechanism relies on the activity of two types of chemosensory neurons: one (AWA) coding gradients via stochastic pulsatile dynamics, and the second (AWC(ON)) coding the gradients deterministically in a graded manner. The pulsatile dynamics of the AWA neuron adapts to the magnitude of the gradient derivative, allowing animals to take trajectories better oriented toward the target. The robust response of AWC(ON) to negative derivatives promotes immediate turns, thus alleviating the costs incurred by erroneous turns dictated by the AWA neuron. This mechanism empowers an efficient navigation strategy that outperforms the classical biased-random walk strategy. This general mechanism thus may be applicable to other sensory modalities for efficient gradient-based navigation. Nature Publishing Group UK 2018-07-20 /pmc/articles/PMC6054637/ /pubmed/30030432 http://dx.doi.org/10.1038/s41467-018-05151-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Itskovits, Eyal Ruach, Rotem Kazakov, Alexander Zaslaver, Alon Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans |
title | Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans |
title_full | Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans |
title_fullStr | Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans |
title_full_unstemmed | Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans |
title_short | Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans |
title_sort | concerted pulsatile and graded neural dynamics enables efficient chemotaxis in c. elegans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054637/ https://www.ncbi.nlm.nih.gov/pubmed/30030432 http://dx.doi.org/10.1038/s41467-018-05151-2 |
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