Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer

Pancreatic neuroendocrine tumors (pNETs) are uncommon cancers arising from pancreatic islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression of 57 sporadic well-differentiated pNETs. pNET genomes are dominated by aneuploidy, leading to concordant changes in RNA ex...

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Detalles Bibliográficos
Autores principales: Lawrence, Ben, Blenkiron, Cherie, Parker, Kate, Tsai, Peter, Fitzgerald, Sandra, Shields, Paula, Robb, Tamsin, Yeong, Mee Ling, Kramer, Nicole, James, Sarah, Black, Mik, Fan, Vicky, Poonawala, Nooriyah, Yap, Patrick, Coats, Esther, Woodhouse, Braden, Ramsaroop, Reena, Yozu, Masato, Robinson, Bridget, Henare, Kimiora, Koea, Jonathan, Johnston, Peter, Carroll, Richard, Connor, Saxon, Morrin, Helen, Elston, Marianne, Jackson, Christopher, Reid, Papaarangi, Windsor, John, MacCormick, Andrew, Babor, Richard, Bartlett, Adam, Damianovich, Dragan, Knowlton, Nicholas, Grimmond, Sean, Findlay, Michael, Print, Cristin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054670/
https://www.ncbi.nlm.nih.gov/pubmed/30062048
http://dx.doi.org/10.1038/s41525-018-0058-3

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