An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we discovered that adeno-associated virus (AA...

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Detalles Bibliográficos
Autores principales: Duncan, Gregg A., Kim, Namho, Colon-Cortes, Yanerys, Rodriguez, Jason, Mazur, Marina, Birket, Susan E., Rowe, Steven M., West, Natalie E., Livraghi-Butrico, Alessandra, Boucher, Richard C., Hanes, Justin, Aslanidi, George, Suk, Jung Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054694/
https://www.ncbi.nlm.nih.gov/pubmed/30038933
http://dx.doi.org/10.1016/j.omtm.2018.03.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054694/
https://www.ncbi.nlm.nih.gov/pubmed/30038933
http://dx.doi.org/10.1016/j.omtm.2018.03.006

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