Cargando…

Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection

BACKGROUND: Recent studies have suggested that the lymph node ratio (LNR) is a prognostic indicator for various malignancies. However, LNR has not been evaluated in colorectal liver-only metastasis (CRLM). This study aimed to investigate the prognostic value of LNR in patients with CRLM after curati...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Yuxiang, Peng, Jianhong, Zhao, Yujie, Sui, Qiaoqi, Zhao, Ruixia, Lu, Zhenhai, Qiu, Miaozhen, Lin, Junzhong, Pan, Zhizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054757/
https://www.ncbi.nlm.nih.gov/pubmed/30140159
http://dx.doi.org/10.2147/CMAR.S169029
_version_ 1783341059129999360
author Deng, Yuxiang
Peng, Jianhong
Zhao, Yujie
Sui, Qiaoqi
Zhao, Ruixia
Lu, Zhenhai
Qiu, Miaozhen
Lin, Junzhong
Pan, Zhizhong
author_facet Deng, Yuxiang
Peng, Jianhong
Zhao, Yujie
Sui, Qiaoqi
Zhao, Ruixia
Lu, Zhenhai
Qiu, Miaozhen
Lin, Junzhong
Pan, Zhizhong
author_sort Deng, Yuxiang
collection PubMed
description BACKGROUND: Recent studies have suggested that the lymph node ratio (LNR) is a prognostic indicator for various malignancies. However, LNR has not been evaluated in colorectal liver-only metastasis (CRLM). This study aimed to investigate the prognostic value of LNR in patients with CRLM after curative resection. PATIENTS AND METHODS: We retrospectively investigated the clinicopathologic features of 154 CRLM patients who underwent curative resection between 2005 and 2015. We classified patients into low and high groups based on their LNR by using the X-tile software. Survival curves were plotted through Kaplan–Meier method and compared by log-rank test. Cox proportional hazards analysis was performed to identify the factors associated with recurrence-free survival (RFS) and overall survival (OS). RESULTS: The patients were divided into two groups in which 124 patients were identified as LNR ≤0.33 and 30 patients as LNR >0.33. Compared to low LNR, high LNR was significantly associated with poor 3-year RFS (47.2% vs 16.7%, P=0.001) and OS (72.8% vs 45.3%, P=0.003) rates. Multivariate analysis indicated that the LNR was an independent predictor for 3-year RFS (hazard ratio, 2.124; 95% CI, 1.339–3.368; P=0.001) and OS (HR, 2.287; 95% CI, 1.282–4.079; P=0.005). However, the node (N) stage and lymph node distribution were not significantly associated with the 3-year RFS (P=0.071, P=0.226) or OS (P=0.452, P=0.791) in patients with CRLM. CONCLUSION: This study demonstrated that LNR was an independent predictor for 3-year RFS and OS in patients with CRLM who underwent curative resection and that its prognostic value was superior to that of N stage and lymph node distribution.
format Online
Article
Text
id pubmed-6054757
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-60547572018-08-23 Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection Deng, Yuxiang Peng, Jianhong Zhao, Yujie Sui, Qiaoqi Zhao, Ruixia Lu, Zhenhai Qiu, Miaozhen Lin, Junzhong Pan, Zhizhong Cancer Manag Res Original Research BACKGROUND: Recent studies have suggested that the lymph node ratio (LNR) is a prognostic indicator for various malignancies. However, LNR has not been evaluated in colorectal liver-only metastasis (CRLM). This study aimed to investigate the prognostic value of LNR in patients with CRLM after curative resection. PATIENTS AND METHODS: We retrospectively investigated the clinicopathologic features of 154 CRLM patients who underwent curative resection between 2005 and 2015. We classified patients into low and high groups based on their LNR by using the X-tile software. Survival curves were plotted through Kaplan–Meier method and compared by log-rank test. Cox proportional hazards analysis was performed to identify the factors associated with recurrence-free survival (RFS) and overall survival (OS). RESULTS: The patients were divided into two groups in which 124 patients were identified as LNR ≤0.33 and 30 patients as LNR >0.33. Compared to low LNR, high LNR was significantly associated with poor 3-year RFS (47.2% vs 16.7%, P=0.001) and OS (72.8% vs 45.3%, P=0.003) rates. Multivariate analysis indicated that the LNR was an independent predictor for 3-year RFS (hazard ratio, 2.124; 95% CI, 1.339–3.368; P=0.001) and OS (HR, 2.287; 95% CI, 1.282–4.079; P=0.005). However, the node (N) stage and lymph node distribution were not significantly associated with the 3-year RFS (P=0.071, P=0.226) or OS (P=0.452, P=0.791) in patients with CRLM. CONCLUSION: This study demonstrated that LNR was an independent predictor for 3-year RFS and OS in patients with CRLM who underwent curative resection and that its prognostic value was superior to that of N stage and lymph node distribution. Dove Medical Press 2018-07-17 /pmc/articles/PMC6054757/ /pubmed/30140159 http://dx.doi.org/10.2147/CMAR.S169029 Text en © 2018 Deng et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Deng, Yuxiang
Peng, Jianhong
Zhao, Yujie
Sui, Qiaoqi
Zhao, Ruixia
Lu, Zhenhai
Qiu, Miaozhen
Lin, Junzhong
Pan, Zhizhong
Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection
title Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection
title_full Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection
title_fullStr Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection
title_full_unstemmed Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection
title_short Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection
title_sort lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054757/
https://www.ncbi.nlm.nih.gov/pubmed/30140159
http://dx.doi.org/10.2147/CMAR.S169029
work_keys_str_mv AT dengyuxiang lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection
AT pengjianhong lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection
AT zhaoyujie lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection
AT suiqiaoqi lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection
AT zhaoruixia lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection
AT luzhenhai lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection
AT qiumiaozhen lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection
AT linjunzhong lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection
AT panzhizhong lymphnoderatioasavaluableprognosticfactorforpatientswithcolorectalliveronlymetastasisundergoingcurativeresection