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Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Aldehyde dehydrogenase 2 (ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, ne...

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Autores principales: Panisello-Roselló, Arnau, Lopez, Alexandre, Folch-Puy, Emma, Carbonell, Teresa, Rolo, Anabela, Palmeira, Carlos, Adam, René, Net, Marc, Roselló-Catafau, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054945/
https://www.ncbi.nlm.nih.gov/pubmed/30038465
http://dx.doi.org/10.3748/wjg.v24.i27.2984
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author Panisello-Roselló, Arnau
Lopez, Alexandre
Folch-Puy, Emma
Carbonell, Teresa
Rolo, Anabela
Palmeira, Carlos
Adam, René
Net, Marc
Roselló-Catafau, Joan
author_facet Panisello-Roselló, Arnau
Lopez, Alexandre
Folch-Puy, Emma
Carbonell, Teresa
Rolo, Anabela
Palmeira, Carlos
Adam, René
Net, Marc
Roselló-Catafau, Joan
author_sort Panisello-Roselló, Arnau
collection PubMed
description Aldehyde dehydrogenase 2 (ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases and aging. A growing body of research has shown that ALDH2 provides important protection against oxidative stress and the subsequent loading of toxic aldehydes such as 4-hydroxy-2-nonenal and adducts that occur in human diseases, including ischemia reperfusion injury (IRI). There is increasing evidence of its role in IRI pathophysiology in organs such as heart, brain, small intestine and kidney; however, surprisingly few studies have been carried out in the liver, where ALDH2 is found in abundance. This study reviews the role of ALDH2 in modulating the pathways involved in the pathophysiology of IRI associated with oxidative stress, autophagy and apoptosis. Special emphasis is placed on the role of ALDH2 in different organs, on therapeutic “preconditioning” strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI in organ transplantation.
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spelling pubmed-60549452018-07-23 Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update Panisello-Roselló, Arnau Lopez, Alexandre Folch-Puy, Emma Carbonell, Teresa Rolo, Anabela Palmeira, Carlos Adam, René Net, Marc Roselló-Catafau, Joan World J Gastroenterol Minireviews Aldehyde dehydrogenase 2 (ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases and aging. A growing body of research has shown that ALDH2 provides important protection against oxidative stress and the subsequent loading of toxic aldehydes such as 4-hydroxy-2-nonenal and adducts that occur in human diseases, including ischemia reperfusion injury (IRI). There is increasing evidence of its role in IRI pathophysiology in organs such as heart, brain, small intestine and kidney; however, surprisingly few studies have been carried out in the liver, where ALDH2 is found in abundance. This study reviews the role of ALDH2 in modulating the pathways involved in the pathophysiology of IRI associated with oxidative stress, autophagy and apoptosis. Special emphasis is placed on the role of ALDH2 in different organs, on therapeutic “preconditioning” strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI in organ transplantation. Baishideng Publishing Group Inc 2018-07-21 2018-07-21 /pmc/articles/PMC6054945/ /pubmed/30038465 http://dx.doi.org/10.3748/wjg.v24.i27.2984 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Panisello-Roselló, Arnau
Lopez, Alexandre
Folch-Puy, Emma
Carbonell, Teresa
Rolo, Anabela
Palmeira, Carlos
Adam, René
Net, Marc
Roselló-Catafau, Joan
Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_full Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_fullStr Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_full_unstemmed Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_short Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_sort role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: an update
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054945/
https://www.ncbi.nlm.nih.gov/pubmed/30038465
http://dx.doi.org/10.3748/wjg.v24.i27.2984
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