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Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease

A recent randomized study of whipworm Trichuris suis ova (TSO) in ileal Crohn’s disease failed to demonstrate a clinical benefit compared to placebo after 12 weeks. Nonetheless, it has recently been shown that the spontaneous small intestinal inflammatory changes in Nod2(-/-) (Nucleotide-binding oli...

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Autores principales: Jaeger, Simon U., Schaeffeler, Elke, Winter, Stefan, Tremmel, Roman, Schölmerich, Jürgen, Malek, Nisar, Stange, Eduard F., Schwab, Matthias, Wehkamp, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054957/
https://www.ncbi.nlm.nih.gov/pubmed/30061834
http://dx.doi.org/10.3389/fphar.2018.00764
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author Jaeger, Simon U.
Schaeffeler, Elke
Winter, Stefan
Tremmel, Roman
Schölmerich, Jürgen
Malek, Nisar
Stange, Eduard F.
Schwab, Matthias
Wehkamp, Jan
author_facet Jaeger, Simon U.
Schaeffeler, Elke
Winter, Stefan
Tremmel, Roman
Schölmerich, Jürgen
Malek, Nisar
Stange, Eduard F.
Schwab, Matthias
Wehkamp, Jan
author_sort Jaeger, Simon U.
collection PubMed
description A recent randomized study of whipworm Trichuris suis ova (TSO) in ileal Crohn’s disease failed to demonstrate a clinical benefit compared to placebo after 12 weeks. Nonetheless, it has recently been shown that the spontaneous small intestinal inflammatory changes in Nod2(-/-) (Nucleotide-binding oligomerization domain 2) mice could be substantially ameliorated when these mice were colonized by Trichuris muris. Those and complementary epidemiologic findings in humans lead to the hypothesis that helminths may be advantageous only in patients carrying defective NOD2 variants. Thus, 207 participants of the TSO trial were retrospectively genotyped for six functional NOD2 genetic variants to evaluate whether the treatment outcome differed in patients carrying NOD2 variants. We observed no significant association of the NOD2 variants or their haplotypes with clinical outcome after TSO treatment.
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spelling pubmed-60549572018-07-30 Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease Jaeger, Simon U. Schaeffeler, Elke Winter, Stefan Tremmel, Roman Schölmerich, Jürgen Malek, Nisar Stange, Eduard F. Schwab, Matthias Wehkamp, Jan Front Pharmacol Pharmacology A recent randomized study of whipworm Trichuris suis ova (TSO) in ileal Crohn’s disease failed to demonstrate a clinical benefit compared to placebo after 12 weeks. Nonetheless, it has recently been shown that the spontaneous small intestinal inflammatory changes in Nod2(-/-) (Nucleotide-binding oligomerization domain 2) mice could be substantially ameliorated when these mice were colonized by Trichuris muris. Those and complementary epidemiologic findings in humans lead to the hypothesis that helminths may be advantageous only in patients carrying defective NOD2 variants. Thus, 207 participants of the TSO trial were retrospectively genotyped for six functional NOD2 genetic variants to evaluate whether the treatment outcome differed in patients carrying NOD2 variants. We observed no significant association of the NOD2 variants or their haplotypes with clinical outcome after TSO treatment. Frontiers Media S.A. 2018-07-16 /pmc/articles/PMC6054957/ /pubmed/30061834 http://dx.doi.org/10.3389/fphar.2018.00764 Text en Copyright © 2018 Jaeger, Schaeffeler, Winter, Tremmel, Schölmerich, Malek, Stange, Schwab and Wehkamp. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jaeger, Simon U.
Schaeffeler, Elke
Winter, Stefan
Tremmel, Roman
Schölmerich, Jürgen
Malek, Nisar
Stange, Eduard F.
Schwab, Matthias
Wehkamp, Jan
Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease
title Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease
title_full Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease
title_fullStr Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease
title_full_unstemmed Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease
title_short Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease
title_sort influence of nod2 variants on trichuris suis ova treatment outcome in crohn’s disease
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054957/
https://www.ncbi.nlm.nih.gov/pubmed/30061834
http://dx.doi.org/10.3389/fphar.2018.00764
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