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Interleukin-35 Inhibits TNF-α-Induced Osteoclastogenesis and Promotes Apoptosis via Shifting the Activation From TNF Receptor-Associated Death Domain (TRADD)–TRAF2 to TRADD–Fas-Associated Death Domain by JAK1/STAT1

Over-activated osteoclasts derived from myeloid or peripheral blood monocytes by inflammatory cytokines results in osteoporosis, osteoarthritis, and other bone erosion-related diseases. Interleukin 35 (IL-35) is a novel anti-inflammatory and immunosuppressive factor. This study investigated the effe...

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Detalles Bibliográficos
Autores principales:	Peng, Mingzheng, Wang, Yanguo, Qiang, Lei, Xu, Yan, Li, Cuidi, Li, Tao, Zhou, Xiaojun, Xiao, Ming, Wang, Jinwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054960/ https://www.ncbi.nlm.nih.gov/pubmed/30061878 http://dx.doi.org/10.3389/fimmu.2018.01417

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