Rad5, HLTF, and SHPRH: A Fresh View of an Old Story

Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with se...

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Detalles Bibliográficos
Autores principales: Elserafy, Menattallah, Abugable, Arwa A., Atteya, Reham, El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Trends Journals 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055012/
https://www.ncbi.nlm.nih.gov/pubmed/29807746
http://dx.doi.org/10.1016/j.tig.2018.04.006
Descripción
Sumario:Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches.

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