Rad5, HLTF, and SHPRH: A Fresh View of an Old Story

Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with se...

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Autores principales: Elserafy, Menattallah, Abugable, Arwa A., Atteya, Reham, El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Trends Journals 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055012/
https://www.ncbi.nlm.nih.gov/pubmed/29807746
http://dx.doi.org/10.1016/j.tig.2018.04.006
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author Elserafy, Menattallah
Abugable, Arwa A.
Atteya, Reham
El-Khamisy, Sherif F.
author_facet Elserafy, Menattallah
Abugable, Arwa A.
Atteya, Reham
El-Khamisy, Sherif F.
author_sort Elserafy, Menattallah
collection PubMed
description Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches.
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spelling pubmed-60550122018-08-01 Rad5, HLTF, and SHPRH: A Fresh View of an Old Story Elserafy, Menattallah Abugable, Arwa A. Atteya, Reham El-Khamisy, Sherif F. Trends Genet Article Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches. Elsevier Trends Journals 2018-08 /pmc/articles/PMC6055012/ /pubmed/29807746 http://dx.doi.org/10.1016/j.tig.2018.04.006 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elserafy, Menattallah
Abugable, Arwa A.
Atteya, Reham
El-Khamisy, Sherif F.
Rad5, HLTF, and SHPRH: A Fresh View of an Old Story
title Rad5, HLTF, and SHPRH: A Fresh View of an Old Story
title_full Rad5, HLTF, and SHPRH: A Fresh View of an Old Story
title_fullStr Rad5, HLTF, and SHPRH: A Fresh View of an Old Story
title_full_unstemmed Rad5, HLTF, and SHPRH: A Fresh View of an Old Story
title_short Rad5, HLTF, and SHPRH: A Fresh View of an Old Story
title_sort rad5, hltf, and shprh: a fresh view of an old story
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055012/
https://www.ncbi.nlm.nih.gov/pubmed/29807746
http://dx.doi.org/10.1016/j.tig.2018.04.006
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